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Review: Adiponectin for prediction of cardiovascular risk?Division of Cardiac and Vascular Sciences, St George's University of London, UK, Adipokines & Metabolism Research Group, Centre for Clinical Pharmacology, University College London, London, UK
Adipokines & Metabolism Research Group, Centre for Clinical Pharmacology, University College London, London, UK
Division of Cardiac and Vascular Sciences, St George's University of London, UK
Division of Cardiac and Vascular Sciences, St George's University of London, UK, jkaski{at}sgul.ac.uk Adiponectin is an endogenous insulin-sensitising and anti-inflammatory hormone, released by the adipose tissue. Because of its in vitro effects on endothelial cells, macrophages and vascular smooth muscle cells, adiponectin is thought to have anti-atherogenic properties. Moreover, findings from the Health Professionals Follow-up Studies and other cohort studies, mainly in male populations, suggest that adiponectin may be an independent predictor for cardiovascular risk. This, however, was not confirmed by subsequent studies that included female subjects, different ethnicities and patients with established coronary artery disease. The present article briefly summarises recent findings regarding the potential role of adiponectin as a predictor of risk and its biological role. Br J Diabetes Vasc Dis 2009;9: 150—154
Key Words: adiponectin • adipose tissue • cardiovascular risk.
The British Journal of Diabetes & Vascular Disease, Vol. 9, No. 4,
150-154 (2009) |
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