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HbA_1c - changing units

School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK, cday{at}mededuk.com

Clifford J Bailey

School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK

Measurement of glycated haemoglobin A_1C (HbA_1C) provides an indication of longer-term glycaemic control. Standardisation of this test between laboratories is difficult to achieve, and most assays are currently calibrated to the values used in the Diabetes Control and Complications Trial (DCCT-aligned). With the availability of more specific reference standards it is now proposed that HbA_1C is expressed as mmol HbA_1C per mol of non-glycated haemoglobin. An HbA_1C of 7% is approximately equal to 53 mmol/mol.

Key Words: estimated average glucose • glycaemic control • glycated haemoglobin • HbA1C • HbA1C units

References

• Pickup JC Diabetic control and its measurement. In: Pickup JC and Williams G (eds.). Textbook of Diabetes. Vol 1. 3rd edn. Oxford: Blackwell Science, 2003;34.1-17.
• Rahbar S. The discovery of glycated hemoglobin: A major event in the study of nonenzymatic chemistry in biological systems. Ann NY Acad Sci 2005;1043:9-19.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Jeffcoate SL Diabetes control and compliations: the role of glycated haemoglobin, 25 years on. Diabetic Med 2003;21:657-65.[CrossRef][Web of Science]
• Jeppsson JG, Kobold U., Barr J. et al. Approved IFCC reference method for the measurement of HbA1C in human blood. Clin Chem Lab Med 2002;40:78-89.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Consensus Committee. Consensus statement on the worldwide standardization of the hemoglobin A1C measurement: the American Diabetes Association, European Association for the Study of Diabetes, International Federation of Clinical Chemistry and Laboratory Medicine, and the International Diabetes Federation. Diabetes Care 2007; 30: 2399-400 and Diabetologia 2007;50:2042-3.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• NHS Diabetes. HbA1C standardisation for laboratory professionals. www.diabetes.nhs.uk/reading-room/nhs-diabetes-publications/factsheets/downloads/hba1c_factsheets/hba1c_lab_leaflet.pdf. (Accessed April 2009)
• Nathan DM, Kuenen J., Borg R. et al. A1c-derived average glucose study group. Translating the A1C assay into estimated average glucose results. Diabetes Care 2008;31:1473-8.[Abstract/Free Full Text]
• Barth JH, Marshall SM, Watson ID Consensus meeting on reporting glycated haemoglobin HbA1C and estimated average glucose (eAG) in the UK: report to the National Director for Diabetes, Department of Health. Diabet Med 2008;25:381-2.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Rohlfing CL, Wiedmeyer HM, Little RR et al. Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care 2002;25:275-8.[Abstract/Free Full Text]
• Krentz AJ, Bailey CJ Type 2 diabetes in practice. 2nd edn. London: Royal Society of Medicine, 2005, pp 206.

The British Journal of Diabetes & Vascular Disease, Vol. 9, No. 3, 134-136 (2009)
DOI: 10.1177/1474651409106110


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Day, C. Articles by Bailey, C. J Search for Related Content Social Bookmarking                         What's this?