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The British Journal of Diabetes & Vascular Disease
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Diabetes treatments, gastrointestinal symptoms and lower gastrointestinal endoscopy

Alex J Kent

Gastroenterology Department, Chelsea and Westminster Hospital NHS Trust, London, UK, alex.kent{at}ndm.ox.ac.uk

Bethan Graf

Gastroenterology Department, Chelsea and Westminster Hospital NHS Trust, London, UK

Priyajit Prasad

Gastroenterology Department, Chelsea and Westminster Hospital NHS Trust, London, UK

Matthew R Banks

Gastroenterology Department, Chelsea and Westminster Hospital NHS Trust, London, UK

Michael D Feher

Beta Cell Diabetes Centre, Chelsea and Westminster Hospital NHS Trust, London, UK

Background. Diabetes mellitus has been associated with an increased incidence of gastrointestinal (GI) symptoms, possibly related to diabetes medications.

Aims. The purpose of our study was to assess the prevalence of GI symptoms and pathology in diabetic subjects referred for lower GI endoscopy.

Results. We identified 31 diabetic patients from 621 patients undergoing lower GI endoscopy over a 6-month period. Diarrhoea and abdominal pain were common symptoms in the diabetic patients. Twelve diabetic subjects were investigated purely for GI symptoms and nine were referred with symptoms potentially related to diabetes medications. In these nine patients only one had an endoscopic diagnosis which accounted for their symptoms. Five patients had normal endoscopies. Conclusion. Diabetic medications may be associated with GI symptoms and alternative medications should be tried before referring for endoscopy.

Key Words: colonoscopy • diabetes • diarrhoea • endoscopy • metformin

References

  • Bytzer P., Talley NJ, Leemon M. et al. Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med 2001;161:1989-96.[Abstract/Free Full Text]
  • Larsson SC, Orsini N., Wolk A. Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst 2005;97:1679-87.[Abstract/Free Full Text]
  • Blonde L., Dailey GE, Jabbour SA et al. Gastrointestinal tolerability of extended-release metformin tablets compared to immediate-release metformin tablets: results of a retrospective cohort study. Curr Med Res Opin 2004;20:565-72.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

The British Journal of Diabetes & Vascular Disease, Vol. 9, No. 3, 129-130 (2009)
DOI: 10.1177/1474651409104956


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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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Right arrow Email this article to a friend
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Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kent, A. J
Right arrow Articles by Feher, M. D
Right arrow Search for Related Content
Social Bookmarking
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What's this?