This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Flatt, P. R Articles by Bailey, C. J Search for Related Content Social Bookmarking                         What's this?

Review: Bariatric surgery: to treat diabesity

School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK

Caroline Day

Diabetes Research Group, Aston University, Birmingham, UK

Clifford J Bailey

Diabetes Research Group, Aston University, Birmingham, UK, c.j.bailey{at}aston.ac.uk

In obese patients bariatric surgery is increasing in popularity as a strategy to promote, and maintain, weight loss. In obese type 2 diabetes bypass, bariatric surgery improves glycaemic control — often to a greater extent than would be anticipated by weight loss alone. Surgical bypass procedures appear to initially offer a greater glucose-lowering effect than surgical restriction procedures. This review considers the rationale for bariatric surgery as a treatment for diabesity and the implications of the different procedures on the secretion and action of enteral hormones.

Key Words: bariatric surgery • GIP • GLP-1 • obesity • type 2 diabetes

References

• Scheen AJ, Lefèbvre PJ Management of the obese diabetic patient. Diabetes Reviews 1999;7:77-93.[Web of Science]
• Henry RR, Gumbiner B. Benefits and limitations of very-low calorie diet therapy in obese NIDDM. Diabetes Care 1991;14:802-23.[Abstract]
• Wing RR, Koeske R., Epstein LH et al. Long-term effects of modest weight loss in type II diabetic patients. Arch Intern Med 1987;147:1749-53.[Abstract/Free Full Text]
• Kelley DE Effects of weight loss on glucose homeostasis in NIDDM. Diabetes Reviews 1995;3:366-77.
• Goldstein DJ Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord 1992;16:397-415.[Web of Science][Medline] [Order article via Infotrieve]
• Pinkney J., Kerrigan D. When should bariatric surgery be used in the treatment of type 2 diabetes? Br J Diabetes Vasc Dis 2004;4:232-7.[Abstract/Free Full Text]
• Vetter ML, Cardillo S., Rickels MR, Iqbal N. Narrative review: effect of bariatric surgery on type 2 diabetes mellitus. Ann Intern Med 2009;150:94-103.[Abstract/Free Full Text]
• Buchwald H., Avidor Y., Braunwald E. et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004;292:1724-37.[Abstract/Free Full Text]
• Dixon JB, Pories WJ, O'Brien et al. Surgery as an effective early intervention for diabesity. Diabetes Care 2005;28:472-4.[Free Full Text]
• Herbst CA, Hughes TA, Gwynne JT, Buckwalter KA Gastric bariatric operation in insulin-treated adults. Surgery 1984;95:209-14.[Web of Science][Medline] [Order article via Infotrieve]
• Pories WJ, MacDonald KG, Flickinger EG et al. Is type II diabetes mellitus (NIDDM) a surgical disease? Ann Surg 1992;215:633-43.[Web of Science][Medline] [Order article via Infotrieve]
• Pories WJ, Swanson MS, MacDonald KG et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg 1995;222:339-50.[Web of Science][Medline] [Order article via Infotrieve]
• MacDonald KG, Long SD, Swanson MS et al. The gastric bypass operation reduces the progression and mortality on non-insulin-dependent diabetes mellitus. J Gastrointest Surg 1997;1:213-20.[CrossRef][Medline] [Order article via Infotrieve]
• Schauer PR, Burguera B., Ikramuddin S. et al. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg 2003;238:467-85.[Web of Science][Medline] [Order article via Infotrieve]
• Sugerman HJ, Wolfe LG, Sica DA, Clore JN Diabetes and hypertension in severe obesity and effects of gastric bypass-induced weight loss. Ann Surg 2003;237:751-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Scheen AJ Aggressive weight reduction treatment in the management of type 2 diabetes. Diabetes Metab 1998;23:116-23.
• Pontiroli AE, Pizzocri P., Librenti MC Laparoscopic adjustable gastric banding for the treatment of morbid (grade 3) obesity and its metabolic complications: a three-year study. J Clin Endocrinol Metab 2002;87:3555-61.[Abstract/Free Full Text]
• Sjostsrom L., Lindroos AK, Peltonen M. et al. Swedish Obese Subjects Study Scientific Group. Lifestyle, diabetes and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004;351:2683-93.[Abstract/Free Full Text]
• Ponce J., Haynes B., Paynter S. et al. Effect of Lap-Band-induced weight loss on type 2 diabetes mellitus and hypertension. Obes Surg 2004;14:1335-42.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Dixon JB, O'Brien PE Health outcomes of severely obese type 2 diabetic subjects 1 year after laparoscopic adjustable gastric banding. Diabetes Care 2002;25:358-63.[Abstract/Free Full Text]
• Dixon JB, O'Brien PE, Playfair J. et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 2008;299:316-23.[Abstract/Free Full Text]
• Flatt PR, Bailey CJ, Green BD Recent advances in antidiabetic drug therapies targeting the enteroinsular axis. Curr Drug Metab 2009;10:125-37.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Flatt PR Effective surgical treatment of obesity may be mediated by ablation of the lipogenic gut hormone gastric inhibitory polypeptide (GIP): evidence and clinical opportunity for development of new obesity-diabetes drugs? Diabetes Vasc Dis Res 2007;4:151-3.
• Meier JJ, Nauck MA, Schmidt WE, Gallwitz B. Gastric inhibitory polypeptide: the neglected incretin revisited. Regul Pept 2002;107:1-13.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Bailey CJ, Wilkes LC, Conlon JM et al. Effects of gastric inhibitory polypeptide, vasoactivie intestinal polypeptide and peptide histidine isoleucine on the secretion of hormones by isolated mouse pancreatic islets. J Endocrinol 1990;125:375-9.[Abstract/Free Full Text]
• Gault VA, Irwin N., Green BD et al. Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro 3) GIP administration improves glucose tolerance and ameliorated insul-n resistance and abnormalities of islet struture in obesity-related diabetes. Diabetes 2005;54:2436-41.[Abstract/Free Full Text]
• Miyawaki K., Yamada Y., Ban et al. Inhibition of gastric inhibitory polypeptide signalling prevents obesity. Nat Med 2002;8:738-42.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Flatt PR Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes? Diabet Med 2008;25:759-64.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Murphy KG, Dhillo WS, Bloom SR Gut peptides in the regulation of food intake and energy homeostasis. Endrocr Rev 2006;27:719-27.[Abstract/Free Full Text]
• Clements RH, Gonzalez Q., Long CJ et al. Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type 2 diabetes mellitus. Am Surg 2004;70:1-5.[Web of Science][Medline] [Order article via Infotrieve]

The British Journal of Diabetes & Vascular Disease, Vol. 9, No. 3, 103-107 (2009)
DOI: 10.1177/1474651409103927


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Flatt, P. R Articles by Bailey, C. J Search for Related Content Social Bookmarking                         What's this?