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Prevalence of HTLV-1 infection in type 2 diabetic patients in Mashhad, northeastern Iran

Endocrine Research Center, Mashhad Medical University, Mashhad, Iran, taghaviMR{at}mums.ac.ir

Seddigheh Fatemi

Immunology Department, Bu Ali Research Center, Mashhad Medical University, Mashhad, Iran

Objective The aim of this study was to evaluate the prevalence of human T cell leukaemia virus type 1 (HTLV-1) infection among patients with type 2 diabetes mellitus in Mashhad in northeastern Iran.

Methods A total of 266 consecutive type 2 diabetic patients (mean age 54.36±11.58 years) attending our unit were compared with 60,892 non-diabetic blood donors for the presence of HTLV-1 infection. Serological testing for HTLV-1 was undertaken using an enzyme-linked immunosorbent assay, and a polymerase chain reaction (PCR) was performed in positive HTLV-1 samples.

Results PCR confirmed HTLV-1 infection in ten patients. The prevalence of HTLV-1 infection was more than five-fold higher in the diabetic patients than the blood donor group (3.75 vs. 0.663%; p<0.001). There was no apparent association between HTLV-1 infection and age, sex, body mass index, diabetes duration or glycaemic control.

Conclusions A higher prevalence of HTLV-1 infection was detected in diabetic patients and this should be borne in mind when treating type 2 diabetic patients in regions where HTLV-1 infection is endemic. Br J Diabetes Vasc Dis 2009; 9:81—83

Key Words: human T cell leukaemia virus type 1 • HTLV-1 • type 2 diabetes • Iran • prevalence.

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The British Journal of Diabetes & Vascular Disease, Vol. 9, No. 2, 81-83 (2009)
DOI: 10.1177/1474651409103583


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Taghavi, M. Articles by Fatemi, S. Search for Related Content Social Bookmarking                         What's this?