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Drug use in gestational diabetes

Section of Reproductive and Developmental Medicine, University of Sheffield, Jessop Wing, Sheffield S10 2SF, UK, g.m.burkinshaw{at}sheffield.ac.uk

There has been a traditional reluctance to recommend oral antidiabetic drugs for the management of hyperglycaemia in gestational diabetes mellitus. Recent publications suggest that both sulphonylureas and metformin may have a contribution to therapy in this condition and in particular the Metformin in Gestational Diabetes (MiG) trial provides good quality evidence that this drug might be particularly suitable when obesity is a factor in gestational diabetes. This article gives an overview of the rationale for use of oral antidiabetic agents in the treatment of gestational diabetes. Br J Diabetes Vasc Dis 2009;9:33—35

Key Words: gestational diabetes • insulin therapy • oral antidiabetic drugs • metformin • glibenclamide • glyburide

References

• Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JR The Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS). Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005;352:2477-86.[Abstract/Free Full Text]
• Stowers JM, Sutherland HW. The use of sulphonylureas, biguanides and insulin in pregnancy. In: Sutherland HW and Stowers JM (eds). Carbohydrate Metabolism in Pregnancy and the Newborn. Edinburgh: Churchill Livingstone, 1975; 205-220.
• O'Sullivan JB, Gellis SS, Dondrow RV, Tenney BO The potential diabetic and her treatment during pregnancy. Obstet Gynecol 1966;27:683-9.[Web of Science][Medline] [Order article via Infotrieve]
• Persson B., Stangenberg M., Hansson U., Nordlander E. Gestational Diabetes Mellitus (GDM) Comparative evaluation of two treatment regimens, diet versus insulin and diet. Diabetes 1985;34(Suppl 2) 101-5.[Abstract]
• De Veciana M., Major CA, Morgan MA et al. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. N Engl J Med 1995;333:1237-41.[Abstract/Free Full Text]
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• Rowan JA, Hague WM, Gao W., Battin MR, Moore MP Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 2008;358:2003-15.[Abstract/Free Full Text]

The British Journal of Diabetes & Vascular Disease, Vol. 9, No. 1, 33-35 (2009)
DOI: 10.1177/1474651408101374


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Fraser, R. Search for Related Content Social Bookmarking                         What's this?