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Clinical variables associated with non-dipping of nocturnal blood pressure in type 2 diabetes

Metabolic Unit, Western General Hospital, Edinburgh, UK

Lorna Robinson

Metabolic Unit, Western General Hospital, Edinburgh, UK

Paul L Padfield

Metabolic Unit, Western General Hospital, Edinburgh, UK

Mark WJ Strachan

Metabolic Unit, Western General Hospital, Edinburgh, UK, mark.strachan{at}luht.scot.nhs.uk

Aim

Non-dipping of nocturnal BP (blood pressure) is common in people with type 2 diabetes and is associated with increased risk of cardiovascular morbidity and mortality. This study aimed to identify the factors associated with nocturnal non-dipping of BP in people with type 2 diabetes.

Methods

Data were examined from 100 people with type 2 diabetes who had undergone ambulatory BP monitoring. Dippers were defined as those with a systolic night-time BP dip over 15%, and non-dippers as those with a systolic night-time BP dip of under 5%.

Results

There was no significant difference between the mean awake systolic BP in the dipping (142.9 mmHg) and the non-dipping (142.0 mmHg) groups (p=0.77). Non-dippers were significantly older (p<0.0001) with a higher prevalence of albuminuria (p=0.003) and of macrovascular disease (p=0.008) when compared with the dipping group. After adjustment for age, albuminuria remained more prevalent within the non-dipping group (p=0.007). There was no significant difference in glycaemic control, type of diabetes treatment, smoking status, or gender between the groups.

Conclusion

Albuminuria is strongly associated with non-dipping of nocturnal BP in people with type 2 diabetes.

Key Words: ambulatory blood pressure • dipping • non-dipping type 2 diabetes.

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The British Journal of Diabetes & Vascular Disease, Vol. 8, No. 5, 236-240 (2008)
DOI: 10.1177/1474651408096678


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sommerfield, A. J Articles by Strachan, M. W. Search for Related Content Social Bookmarking                         What's this?