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The British Journal of Diabetes & Vascular Disease
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Reviews

Review: Stroke in type 2 diabetes

Dirk Sander

Department of Neurology, Medical Park Hospital, Bischofswiesen Germany, D.Sander{at}mac.com, Department of Neurology, University of Technology, Munich, Germany

Kerstin Sander

Department of Neurology, Medical Park Hospital, Bischofswiesen Germany, Department of Neurology, University of Technology, Munich, Germany

Holger Poppert

Department of Neurology, University of Technology, Munich, Germany

Stroke is the second most frequent cause of death worldwide and the most frequent cause of permanent disability. Patients with diabetes are at 1.5 to three times the risk of stroke compared with the general population. Cerebrovascular disease causes 20% of deaths in diabetic patients. Interestingly, there are some striking differences of stroke patterns between diabetic and non-diabetic subjects suffering a stroke. Even more important is the fact that diabetes dramatically increases the risk of stroke in younger subjects as well as women. These data highlight the need for detection and treatment of diabetes particularly in these patient groups. This review summarises several aspects of stroke in type 2 diabetes, focusing on differences from non-diabetic stroke.

Key Words: stroke • diabetes mellitus • epidemiology • risk factors • treatment • sex differences.

References

  • Murray CJ, Lopez AD Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 1997; 349:1269-76.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Sacco RL, Benjamin EJ, Broderick JP et al. American Heart Association Prevention Conference. IV. Prevention and Rehabilitation of Stroke. Risk factors. Stroke 1997; 28:1507-17.[Free Full Text]
  • Bell DS Stroke in the diabetic patient. Diabetes Care 1994; 17:213-19.[Abstract]
  • Kissela BM, Khoury J., Kleindorfer D. et al. Epidemiology of ischemic stroke in patients with diabetes: the greater Cincinnati/Northern Kentucky Stroke Study. Diabetes Care 2005; 28:355-9.[Abstract/Free Full Text]
  • Folsom AR, Rasmussen ML, Chambless LE et al. Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Diabetes Care 1999; 22:1077-83.[Abstract/Free Full Text]
  • Mankovsky BN, Metzger BE, Molitch ME, Biller J. Cerebrovascular disorders in patients with diabetes mellitus. J Diabetes Complications 1996; 10:228-42.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Jorgensen H., Nakayama H., Raaschou HO, Olsen TS Stroke in patients with diabetes. The Copenhagen Stroke Study. Stroke 1994; 25:1977-84.[Abstract]
  • Boden-Albala B., Sacco RL, Lee HS et al. Metabolic syndrome and ischemic stroke risk: Northern Manhattan Study. Stroke 2008; 39:30-5.[Abstract/Free Full Text]
  • Arauz A., Murillo L., Cantu C., Barinagarrementeria F., Higuera J. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases. Stroke 2003; 34:2453-8.[Abstract/Free Full Text]
  • Eguchi K., Kario K., Shimada K. Greater impact of coexistence of hypertension and diabetes on silent cerebral infarcts. Stroke 2003; 34:2471-4.[Abstract/Free Full Text]
  • Tuttolomondo A., Pinto A., Salemi G. et al. Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome. Nutr Metab Cardiovasc Dis 2008; 18:152-7.
  • Hankey GJ, Jamrozik K., Broadhurst RJ et al. Long-term risk of first recurrent stroke in the Perth Community Stroke Study. Stroke 1998; 29:2491-500.[Abstract/Free Full Text]
  • Nannetti L., Paci M., Baccini M., Rinaldi LA, Taiti PG Recovery from stroke in patients with diabetes mellitus. J Diabetes Complications 2008 Apr 14 [Epub ahead of print].
  • Megherbi SE, Milan C., Minier D. et al. Association between diabetes and stroke subtype on survival and functional outcome 3 months after stroke: data from the European BIOMED Stroke Project. Stroke 2003; 34:688-94.[Abstract/Free Full Text]
  • Tuomilehto J., Rastenyte D., Jousilahti P., Sarti C., Vartiainen E. Diabetes mellitus as a risk factor for death from stroke. Prospective study of the middle-aged Finnish population. Stroke 1996; 27:210-15.[Abstract/Free Full Text]
  • Sprafka JM, Virnig BA, Shahar E., McGovern PG Trends in diabetes prevalence among stroke patients and the effect of diabetes on stroke survival: the Minnesota Heart Survey. Diabet Med 1994; 11:678-84.[Web of Science][Medline] [Order article via Infotrieve]
  • Olsson T., Viitanen M., Asplund K., Eriksson S., Hagg E. Prognosis after stroke in diabetic patients. A controlled prospective study. Diabetologia 1990; 33:244-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Luchsinger JA, Tang MX, Stern Y., Shea S., Mayeux R. Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multi-ethnic cohort. Am J Epidemiol 2001; 154:635-41.[Abstract/Free Full Text]
  • Mulnier HE, Seaman HE, Raleigh VS et al. Risk of stroke in people with type 2 diabetes in the UK: a study using the General Practice Research Database. Diabetologia 2006; 49:2859-65.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hu G., Sarti C., Jousilahti P. et al. The impact of history of hypertension and type 2 diabetes at baseline on the incidence of stroke and stroke mortality. Stroke 2005; 36:2538-43.[Abstract/Free Full Text]
  • Giorda CB, Avogaro A., Maggini M. et al. Incidence and risk factors for stroke in type 2 diabetic patients: the DAI study. Stroke 2007; 38:1154-60.[Abstract/Free Full Text]
  • Kang SS, Littooy FN, Gupta SR et al. Higher prevalence of abdominal aortic aneurysms in patients with carotid stenosis but without diabetes. Surgery 1999; 126:687-91; discussion 691-2.[Web of Science][Medline] [Order article via Infotrieve]
  • Ahari A., Bergqvist D., Troeng T. et al. Diabetes mellitus as a risk factor for early outcome after carotid endarterectomy: a population-based study. Eur J Vasc Endovasc Surg 1999; 18:122-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Kuhan G., Gardiner ED, Abidia AF et al. Risk modelling study for carotid endarterectomy. Br J Surg 2001; 88:1590-4.[Medline] [Order article via Infotrieve]
  • Poppert H., Wolf O., Theiss W. et al. MRI lesions after invasive therapy of carotid artery stenosis: a risk-modeling analysis. Neurol Res 2006; 28:563-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Moreno PR, Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol 2004; 44:2293-300.[Abstract/Free Full Text]
  • Yokoyama H., Katakami N., Yamasaki Y. Recent advances of intervention to inhibit progression of carotid intima-media thickness in patients with type 2 diabetes mellitus. Stroke 2006; 37:2420-7.[Abstract/Free Full Text]
  • Tiehuis AM, van der Graaf Y., Visseren FL et al. Diabetes increases atrophy and vascular lesions on brain MRI in patients with symptomatic arterial disease. Stroke 2008; 39:1600-03.[Abstract/Free Full Text]
  • Honda M., Kitagawa N., Tsutsumi K. et al. High-resolution magnetic resonance imaging for detection of carotid plaques. Neurosurgery 2006; 58:338-46; discussion 338-46.[CrossRef][Medline] [Order article via Infotrieve]
  • Esposito L., Sievers M., Sander D. et al. Detection of unstable carotid artery stenosis using MRI. J Neurol 2007; 254:1714-22.[Medline] [Order article via Infotrieve]
  • Takaya N., Yuan C., Chu B. et al. Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI: initial results. Stroke 2006; 37: 818-23.[Abstract/Free Full Text]
  • Lin K., Zhang ZQ, Detrano R., Lu B., Fan ZM Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging study. Acad Radiol 2006; 13:1180-6.[Medline] [Order article via Infotrieve]
  • Esposito L., Heider P., Wolf O. et al. Carotid artery stenosis: diagnosis of diabetes predicts increased vulnerability of plaques irrespective of the degree of stenosis. Cerebrovasc Dis 2008; 25:20.
  • Stevens RJ, Coleman RL, Adler AI et al. Risk factors for myocardial infarction case fatality and stroke case fatality in type 2 diabetes: UKPDS 66. Diabetes Care 2004; 27:201-07.[Abstract/Free Full Text]
  • Epstein M., Sowers JR Diabetes mellitus and hypertension. Hypertension 1992; 19:403-18.[Abstract/Free Full Text]
  • Dahlof B., Devereux RB, Kjeldsen SE et al. Cardiovascular morbidity hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359:995-1003.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Julius S., Kjeldsen SE, Weber M. et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004; 363:2022-31.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Elliott WJ, Meyer PM Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet 2007; 369:201-07.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Yusuf S., Teo KK, Pogue J. et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008; 358:1547-59.[Abstract/Free Full Text]
  • Benjamin EJ, Levy D., Vaziri SM, D'Agostino RB, Belanger AJ, Wolf PA Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA 1994; 271:840-4.[Abstract/Free Full Text]
  • Lakshminarayan K., Anderson DC, Herzog CA, Qureshi AI Clinical epidemiology of atrial fibrillation and related cerebrovascular events in the United States. Neurologist 2008; 14:143-50.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Smith PJ, Hurlen M., Abdelnoor M., Arnesen H. Less benefit from warfarin in diabetics after myocardial infarction? Cardiology 2008; 111:161-6.
  • Sacco RL, Adams R., Albers G. et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Circulation 2006; 113:e409-e449.[Abstract/Free Full Text]
  • Wang TJ, Parise H., Levy D. et al. Obesity and the risk of new-onset atrial fibrillation. JAMA 2004; 292:2471-17.[Abstract/Free Full Text]
  • Shelgikar KM, Hockaday TD, Yajnik CS Central rather than generalized obesity is related to hyperglycaemia in Asian Indian subjects. Diabet Med 1991; 8:712-17.[Web of Science][Medline] [Order article via Infotrieve]
  • Mozaffarian D., Marfisi R., Levantesi G., et al. Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors. Lancet 2007; 370:667-75.[CrossRef][Medline] [Order article via Infotrieve]
  • Tanne D., Koren-Morag N., Goldbourt U. Fasting plasma glucose and risk of incident ischemic stroke or transient ischemic attacks: a prospective cohort study. Stroke 2004; 35:2351-5.[Abstract/Free Full Text]
  • Capes SE, Hunt D., Malmberg K., Pathak P., Gerstein HC Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001; 32:2426-32.[Abstract/Free Full Text]
  • Selvin E., Marinopoulos S., Berkenblit G. et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 2004; 141:421-31.[Abstract/Free Full Text]
  • Batty GD, Kivimaki M., Davey Smith G., Marmot MG, Shipley MJ Post-challenge blood glucose concentration and stroke mortality rates in non-diabetic men in London: 38-year follow-up of the original Whitehall prospective cohort study. Diabetologia 2008; 51:1123-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352:854-65.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998; 352:837-53.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Lehto S., Ronnemaa T., Pyorala K., Laakso M. Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes. Stroke 1996; 27:63-8.[Abstract/Free Full Text]
  • Sacco RL, Benson RT, Kargman DE et al. High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study. JAMA 2001; 285:2729-35.[Abstract/Free Full Text]
  • Amarenco P., Labreuche J., Touboul PJ High-density lipoprotein-cholesterol and risk of stroke and carotid atherosclerosis: a systematic review. Atherosclerosis 2008; 196:489-96.[Medline] [Order article via Infotrieve]
  • Corvol JC, Bouzamondo A., Sirol M., Hulot JS, Sanchez P., Lechat P. Differential effects of lipid-lowering therapies on stroke prevention: a meta-analysis of randomized trials.
  • Colhoun HM, Betteridge DJ, Durrington PN, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004; 364:685-96.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Keech A., Colquhoun D., Best J. et al. Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose: results from the LIPID trial. Diabetes Care 2003; 26:2713-21.[Abstract/Free Full Text]
  • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360:7-22.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Amarenco P., Bogousslavsky J., Callahan A. 3rd et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006; 355:549-59.[Abstract/Free Full Text]
  • Collaborators Cttc, Kearney PM, Blackwell L. et al. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 2008; 371:117-25.[CrossRef][Medline] [Order article via Infotrieve]
  • Pyorala M., Miettinen H., Laakso M., Pyorala K. Hyperinsulinemia and the risk of stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Stroke 1998; 29:1860-6.[Abstract/Free Full Text]
  • Matsumoto K., Miyake S., Yano M. et al. Insulin resistance and classic risk factors in type 2 diabetic patients with different subtypes of ischemic stroke. Diabetes Care 1999; 22:1191-5.[Abstract/Free Full Text]
  • Najarian RM, Sullivan LM, Kannel WB, Wilson PW, D'Agostino RB, Wolf PA Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke: the Framingham Offspring Study. Arch Intern Med 2006; 166:106-11.[Abstract/Free Full Text]
  • Meerarani P., Badimon JJ, Zias E., Fuster V., Moreno PR Metabolic syndrome and diabetic atherothrombosis: implications in vascular complications. Curr Mol Med 2006; 6:501-14.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Bots ML, Hoes AW, Koudstaal PJ, Hofman A., Grobbee DE Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997; 96:1432-7.[Abstract/Free Full Text]
  • Henry RM, Kostense PJ, Dekker JM et al. Carotid arterial remodeling: a maladaptive phenomenon in type 2 diabetes but not in impaired glucose metabolism: the Hoorn study. Stroke 2004; 35:671-6.[Abstract/Free Full Text]
  • Wagenknecht LE, D'Agostino R. Jr, Savage PJ, O'Leary DH, Saad MF, Haffner SM Duration of diabetes and carotid wall thickness. The Insulin Resistance Atherosclerosis Study (IRAS). Stroke 1997; 28: 999-1005.[Abstract/Free Full Text]
  • Howard BV, Roman MJ, Devereux RB et al. Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the SANDS randomized trial. JAMA 2008; 299:1678-89.[Abstract/Free Full Text]
  • Gillett M., Davis WA, Jackson D., Bruce DG, Davis TM Prospective evaluation of carotid bruit as a predictor of first stroke in type 2 diabetes: the Fremantle Diabetes Study. Stroke 2003; 34:2145-51.[Abstract/Free Full Text]
  • Cheung N., Rogers S., Couper DJ, Klein R., Sharrett AR, Wong TY Is diabetic retinopathy an independent risk factor for ischemic stroke? Stroke 2007; 38:398-401.[Abstract/Free Full Text]
  • Lehto S., Niskanen L., Ronnemaa T., Laakso M. Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke 1998; 29:635-9.[Abstract/Free Full Text]
  • Guerrero-Romero F., Rodriguez-Moran M. Proteinuria is an independent risk factor for ischemic stroke in non-insulin-dependent diabetes mellitus. Stroke 1999; 30:1787-91.[Abstract/Free Full Text]
  • Wannamethee SG, Shaper AG, Perry IJ Serum creatinine concentration and risk of cardiovascular disease: a possible marker for increased risk of stroke. Stroke 1997; 28:557-63.[Abstract/Free Full Text]
  • You RX, McNeil JJ, O'Malley HM, Davis SM, Thrift AG, Donnan GA Risk factors for stroke due to cerebral infarction in young adults. Stroke 1997; 28:1913-18.[Abstract/Free Full Text]
  • Jorgensen HS, Nakayama H., Reith J., Raaschou HO, Olsen TS Stroke recurrence: predictors, severity, and prognosis. The Copenhagen Stroke Study. Neurology 1997; 48:891-5.[Abstract/Free Full Text]
  • Idris I., Thomson GA, Sharma JC Diabetes mellitus and stroke. Int J Clin Pract 2006; 60:48-56.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Johnston SC, Rothwell PM, Nguyen-Huynh MN et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 2007; 369:283-92.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Fateh-Moghadam S., Plockinger U., Cabeza N. et al. Prevalence of aspirin resistance in patients with type 2 diabetes. Acta Diabetol 2005; 42:99-103.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Kernan WN, Inzucchi SE, Viscoli CM, Brass LM, Bravata DM, Horwitz RI Insulin resistance and risk for stroke. Neurology 2002; 59:809-15.[Abstract/Free Full Text]
  • Stocker DJ, Taylor AJ, Langley RW, Jezior MR, Vigersky RA A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes. Am Heart J 2007; 153:445e1-e6.
  • Kernan WN, Inzucchi SE, Viscoli CM et al. Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke. Stroke 2003; 34:1431-6.[Abstract/Free Full Text]
  • Takano H., Hasegawa H., Zou Y., Komuro I. Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases. Curr Pharm Des 2004; 10:2779-86.[CrossRef][Medline] [Order article via Infotrieve]
  • Nakamura T., Yamamoto E., Kataoka K. et al. Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure. Stroke 2007; 38:3016-22.[Abstract/Free Full Text]
  • Kielian T., Drew PD Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. J Neurosci Res 2003; 71:315-25.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Tureyen K., Kapadia R., Bowen KK et al. Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J Neurochem 2007; 101:41-56.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wilcox R., Bousser MG, Betteridge DJ et al. Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: results from PROactive (PROspective pioglitAzone Clinical Trial In macroVascular Events 04). Stroke 2007; 38:865-73.[Abstract/Free Full Text]
  • Dormandy JA, Charbonnel B., Eckland DJ et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005; 366:1279-89.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Lincoff AM, Wolski K., Nicholls SJ, Nissen SE Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 2007; 298:1180-8.[Abstract/Free Full Text]

The British Journal of Diabetes & Vascular Disease, Vol. 8, No. 5, 222-229 (2008)
DOI: 10.1177/1474651408096677
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