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Switching basal analogue insulins — short-term weight effects

Beta Cell Diabetes Centre, Chelsea and Westminster Hospital, NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH

YP Samarasinghe

Beta Cell Diabetes Centre, Chelsea and Westminster Hospital, NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH

Niel Munro

Beta Cell Diabetes Centre, Chelsea and Westminster Hospital, NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH

Michael D Feher

Beta Cell Diabetes Centre, Chelsea and Westminster Hospital, NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, michael.feher{at}chelwest.nhs.uk

Efforts to improve glycaemic control in people with diabetes have encouraged more intensive therapeutic approaches. Hypoglycaemia is a risk associated with insulin therapy and a further consequence of intensified treatment is unwanted weight gain. The introduction of the long-acting insulin analogues, glargine and detemir, has provided a circulating insulin profile more reminiscent of normal basal insulin. This has allowed insulin dose escalation with a reduced risk of hypoglycaemia. The current study investigates the effect of switching treatment to insulin detemir in patients who had gained weight on insulin glargine therapy. Two months of treatment with insulin detemir did not alter glycaemic control or insulin dosage, but body weight was significantly reduced in patients with type 1 (p<0.05) and type 2 (p<0.005) diabetes. Br J Diabetes Vasc Dis 2008; 8: 183—186

Key Words: detemir • glargine • insulin analogues • weight gain

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The British Journal of Diabetes & Vascular Disease, Vol. 8, No. 4, 183-186 (2008)
DOI: 10.1177/1474651408094846


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ubogagu, E. Articles by Feher, M. D Search for Related Content Social Bookmarking                         What's this?