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The MERCURY I open-label extension study — subgroup analysis in patients with diabetes

Humboldt University, Berlin, Germany, schuster{at}infogen.de

Mike K Palmer

Keele University, Keele, UK

Marc Ditmarsch

Former-AstraZeneca, Mölndal, Sweden

Background The MERCURY I open-label extension study provides safety and efficacy data on hypercholesterolaemic patients with type 2 diabetes treated with rosuvastatin for up to three years.

Methods A total of 2,492 hypercholesterolaemic patients, including 665 (26.7%) with type 2 diabetes, on rosuvastatin 10 mg or 20 mg were followed for a mean of 672 days in an open-label extension study during which the dose could be increased to 20 or 40 mg to reach the 1998 European low-density lipoprotein-cholesterol (LDL-C) target of < 3.0 mmol/L (< 115 mg/dL)

Results Most diabetic and non-diabetic patients started (85.4 % and 88.7%) and finished (78.3% and 77.6%) on rosuvastatin 10 mg. Adverse event (9.8% and 12.3%) and treatment discontinuation (2.2% and 3.5%) rates were similar in diabetic and non-diabetic patients. No myopathy or rhabdomyolysis was observed. Mean serum creatinine decreased in both subgroups. Proteinuria was reported as an adverse event in five (0.7%) diabetic patients and eight (0.4%) non-diabetic patients. Fasting plasma glucose did not change markedly in either subgroup. LDL-C decreased by 51.1% and 47.4% in diabetic and non-diabetic patients, respectively, with 92.4% and 90.3% reaching target LDL-C.

Conclusion Long-term rosuvastatin treatment is effective and well tolerated in diabetic patients.

Key Words: diabetes • hypercholesterolaemia • low-density lipoprotein-cholesterol goal • rosuvastatin • safety.

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The British Journal of Diabetes & Vascular Disease, Vol. 8, No. 3, 142-147 (2008)
DOI: 10.1177/14746514080080030601


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Schuster, H. Articles by Ditmarsch, M. Search for Related Content Social Bookmarking                         What's this?