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Is non-dipping of nocturnal blood pressure in type 2 diabetes associated with increased incidence of microalbuminuria?

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK

Karen A Adamson

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK, k.a.adamson{at}ed.ac.uk

Riccardo E Marioni

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK

Paul L Padfield

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK

Mark Wj Strachan

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK

icroalbuminuria has been associated with Mnon-dipping of nocturnal blood pressure (BP) in people with type 2 diabetes, but the mechanism of this association is unclear. We aimed to identify the development of microalbuminuria in patients with nocturnal non-dipping of BP and type 2 diabetes. Data were examined from 150 people with type 2 diabetes who had undergone ambulatory BP monitoring, non-dippers were defined as those with a systolic nocturnal BP dip less than 10% of the daytime BP.

The development of microalbuminuria, over five years of follow-up, in dippers and non-dippers was not significantly different. Non-dippers who were microalbuminuric at baseline were more likely to have a higher body mass index (p=0.01) and to be male (p<0.01).

This lack of a difference may be due to the initial exclusion of microalbuminuric patients, who may be genetically predetermined to develop microalbuminuria. Further prospective trials are required to investigate this relationship.

Key Words: ambulatory blood pressure • dipping • nephropathy • non-dipping • type 2 diabetes.

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The British Journal of Diabetes & Vascular Disease, Vol. 8, No. 3, 136-139 (2008)
DOI: 10.1177/14746514080080030501


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Heggie, A. J Articles by Strachan, M. W. Search for Related Content Social Bookmarking                         What's this?