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Inflammation is associated with liver function markers, independent of other metabolic risk factors in overweight women

MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Rd, Cambridge, CB1 9NL, UK, Lucy.Browning{at}mrc-hnr.cam.ac.u

Jeremy D Krebs

MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Rd, Cambridge, CB1 9NL, UK

Mario Siervo

MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Rd, Cambridge, CB1 9NL, UK

Rosemary M Hall

MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Rd, Cambridge, CB1 9NL, UK

Nicholas Finer

Wellcome Clinical Research Facility, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK

Michael ED Allison

Cambridge Hepatobiliary and Liver Transplant Unit, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK

Susan A Jebb

MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Rd, Cambridge, CB1 9NL, UK

Non-alcoholic fatty liver disease, common in Nobesity, is characterised by fatty infiltration to the liver and can progress to steatohepatitis. Inflammation is a predictor of metabolic disease, but the relationship between inflammation and liver disease is unclear. This study determines whether liver function enzymes are associated with markers of systemic inflammation. In a group of 249 overweight women, fasting blood samples were collected and analysed for insulin, glucose, lipids, C-reactive protein (CRP), sialic acid (SA), alanine aminotransferase, alkaline phosphatase (ALP) and -glutamyltransferase.

SA and CRP were significant predictors of ALP concentrations, independent of metabolic syndrome features (β=0.35, p<0.0001 and β=0.20, p=0.004). SA and CRP showed significant incremental increases across groups based on the number of features of metabolic disease, which persisted after adjustement for body mass index (β=0.32, p<0.0001 and =0.16, p=0.02). These data suggest that systemic inflammation is significantly associated with liver function markers, Independent of other metabolic risk factors.

Key Words: C-reactive protein • inflammation • liver function • metabolic syndrome • non-alcoholic fatty liver disease • non-alcoholic steatohepatitis.

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The British Journal of Diabetes & Vascular Disease, Vol. 8, No. 2, 73-76 (2008)
DOI: 10.1177/14746514080080020401


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Browning, L. M Articles by Jebb, S. A Search for Related Content Social Bookmarking                         What's this?