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The British Journal of Diabetes & Vascular Disease
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Review: The role of fenofibrate in reducing cardiovascular risk in type 2 diabetes

Juan Pedro-Botet

Hospital del Mar, Paseo Marítimo, 25-29. 08003 Barcelona, Spain, 86620{at}imas.imim.es

Dyslipidaemia (elevated triglycerides, low high-density lipoprotein-cholesterol [HDL-C] and an increase in small, dense low-density lipoprotein [LDL] particles) is an important contributor to the increased cardiovascular risk associated with type 2 diabetes. Lowering LDL-C levels with a statin is the main focus of lipid-modifying intervention. Fibrates are effective against all components of this atherogenic mixed dyslipidaemia. Adding a fibrate to primary statin therapy is a logical approach to achieving all lipid targets. Evidence from the Fenofibrate Invention and Event Lowering in Diabetes trial also shows that fenofibrate is a well-tolerated option with potential benefits on the progression of microvascular complications of type 2 diabetes. Thus fenofibrate-statin combination therapy may translate into greater reductions in vascular risk.fenofibrate, safety, type 2 diabetes.

Key Words: cardiovascular risk • dyslipidaemia • efficacy • fenofibrate • safety • type 2 diabetes.

References

  • Kannel WB Lipids, diabetes and coronary heart disease: insights from the Framingham Study. Am Heart J 1985;110:1100-07.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Stamler J., Vaccaro O., Neaton JD et al. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993;16:434-44.[Abstract]
  • Huxley R., Barzi F., Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ 2006;332:73-8.[Abstract/Free Full Text]
  • Gu K., Cowie CC, Harris MI Diabetes and decline in heart disease mortality in US adults. JAMA 1999;28:1291-7.
  • Alberti Kgmm, Zimmet P., Shaw J. International Diabetes Federation: a consensus on Type 2 diabetes prevention. Diabetic Medicine 2007;24:451-63.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Blendea MC, McFarlane SI, Isenovic ER et al. Heart disease in diabetic patients. Curr Diabetes Rep 2003;3:223-9.[CrossRef]
  • Unal B., Critchley JA, Capewell S. Explaining the decline in coronary heart disease mortality in England and Wales between 1981 and 2000. Circulation 2004;109:1101-07.[Abstract/Free Full Text]
  • Kendall DM, Bergenstal RM Comprehensive management of patients with type 2 diabetes: establishing priorities of care. Am J Manag Care 2001;7:S327-S43.[Web of Science][Medline] [Order article via Infotrieve]
  • Turner RC, Millns H., Neil HAW et al. Risk factors for coronary artery disease in non-insulin dependent diabete mellitus: United Kingdom prospective diabetes study (UKPDS: 23). BMJ 1998;316:823-8.[Abstract/Free Full Text]
  • Ukpds. U.K. Prospective Diabetes Study 27. Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex. Diabetes Care 1997;20:1683-7.[Abstract]
  • Austin MA, Edwards KL Small, dense low density lipoproteins, the insulin resistance syndrome and O non-insulin-dependent diabetes. Curr Opin Lipidol 1996;7:167-71.[Web of Science][Medline] [Order article via Infotrieve]
  • St-Pierre AC, Cantin B., Dagenais GR et al. (Low-density lipoprotein sub-fractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Quebec Cardiovascular Study. Arterioscler Thromb Vasc Biol 2005;25:553-9.[Abstract/Free Full Text]
  • Eckel RH, Kahn R., Robertson RM, Rizza RA Preventing cardiovascular disease and diabetes. A call to action from the American Diabetes Association and the American Heart Association. Circulation 2006;113:2943-6.[Free Full Text]
  • Jacobs MJ, Kleisli T., Pio JR et al. Prevalence and control of dyslipidaemia among persons with diabetes in the United States. Diabetes Res Clin Pract 2005;70:263-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood pressure in adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.[Free Full Text]
  • Grundy SM, Gleeman JI, Mertz CN et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004;110:227-39.[Abstract/Free Full Text]
  • Stone NJ, Bilek S., Rosenbaum S. Recent National Cholesterol Education Program Adult Treatment Panel III update: adjustments and options. Am J Cardiol 2005;96(suppl): 53E-59E.[Web of Science][Medline] [Order article via Infotrieve]
  • American Diabetes Association. Standards of medical care in diabetes-2006. Diabetes Care 2006;29(suppl 1):S4-S42.[Free Full Text]
  • Smith SC, Allen J., Blair SN et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update. Circulation 2006;113:2363-72.[Free Full Text]
  • Ryden L., Standl E., Bartnik M. et al. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. Eur Heart J 2007;28:88-136.[Free Full Text]
  • Baigent C., Keech A., Kearney PM et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005;366:1267-78.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Costa J., Borges M., David C., Vaz Carneiro A. Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: meta-analysis of randomised controlled trials. BMJ 2006;332:1115-24.[Abstract/Free Full Text]
  • Shepherd J., Barter P., Carmena R. et al. Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes. The Treating to New Targets (TNT) study. Diabetes Care 2006;29:1220-6.[Abstract/Free Full Text]
  • Ravnskov U., Rosch PJ, Sutter MC, Houston MC Should we lower cholesterol as much as possible? BMJ 2006;332:1330-2.[Free Full Text]
  • Chapman MJ Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives. Atherosclerosis 2003;171:1-13.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Fazio S., Linton MF The role of fibrates in managing hyperlipidemia: mechanism of action and clinical efficacy. Curr Atherosclerosis Rep 2004;6:148-57.[CrossRef]
  • Staels B., Dallongeville J., Auwerx J. et al. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998;98:2088-93.[Abstract/Free Full Text]
  • Diabetes Atherosclerosis Intervention Study investigators. Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes; the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 2001;357:905-10.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Keech A., Simes RJ, Barter P. et al. Effect of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005;366:1849-61.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Athyros VG, Papageorgiou AA, Athyrou VV et al. Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hyperlipidemia. Diabetes Care 2002;25:1198-202.[Abstract/Free Full Text]
  • Derosa G., Cicero AE, Bertone G. et al. Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: a 12-month, randomized, double-blind, controlled trial. Clin Ther 2004;26:1599-607.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Durrington PN, Tuomilehto J., Hamann A. et al. Rosuvastatin and fenofibrate alone and in combination in type 2 diabetes patients with combined hyperlipidaemia. Diabetes Res Clin Pract 2004; 64:137-51.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Muhlestein JB, May HT, Jensen JR et al. The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: the DIACOR (Diabetes and Combined Lipid Therapy Regimen) study. J Am Coll Cardiol 2006;48:396-401.[Abstract/Free Full Text]
  • Feher MD, Caslake M., Foxton J. et al. Atherogenic lipoprotein phenotype in type 2 diabetes: reversal with micronised fenofibrate. Diabetes Metab Res Rev 1999;15:395-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Vakkilainen J., Steiner G., Ansquer JC et al. Relationships between low-density lipoprotein particle size, plasma lipoproteins, and progression of coronary artery disease: the Diabetes Atherosclerosis Intervention Study (DAIS). Circulation 2003;107:1733-7.[Abstract/Free Full Text]
  • Corti R., Osende J., Hutter R. et al. Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: in vivo demonstration by high-resolution MRI. Atherosclerosis 2007;190:106-13.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Zambon A., Gervois P., Pauletto P. et al. Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence. Arterioscler Thromb Vasc Biol 2006;26:977-86.[Abstract/Free Full Text]
  • Barbier O., Pineda Torra I., Dugay Y. et al. Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol 2002;22:717-26.[Abstract/Free Full Text]
  • Staels B., Koenig W., Habib A. et al. Activation of human aortic smooth muscle cells is inhibited by PPAR-{alpha} but not by PPAR-{gamma} activators. Nature 1998;393:790-3.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Marx M., Sukhova GK, Collins T. et al. PPAR-{alpha} activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 1999;99:3125-31.[Abstract/Free Full Text]
  • Rubins HB, Robins SJ, Collins D. et al. Diabetes, plasma insulin, and cardiovascular disease. Subgroup analysis from the Department of Veterans Affairs High-density Lipoprotein Intervention Trial (VA-HIT). Arch Intern Med 2002;162:2597-604.[Abstract/Free Full Text]
  • Koskinen P., Mantarri M., Manninen V. et al. Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study. Diabetes Care 1992;15:820-5.[Abstract]
  • Tenkanen L., Mantarri M., Manninen V. Some coronary risk factors related to the insulin resistance syndrome and treatment with gemfibrozil: experience from the Helsinki Heart Study. Circulation 1995;92:1779-85.[Abstract/Free Full Text]
  • Robins SJ, Collins D., Wittes JT et al. Relation of gemfibrozil treatment and lipid levels with major coronary events. VA-HIT: a randomized controlled trial. JAMA 2001;285:1585-91.[Abstract/Free Full Text]
  • Keech T., on behalf of the FIELD study investigators. Effects of long-term fenofibrate therapy on cardiovascular events among 9795 people with type 2 diabetes mellitus: the FIELD study, a randomised controlled trial. Atherosclerosis Suppl 2006;7:342 [Abstract We-S15].
  • Saha SA, Arora RR, Bahekar A. et al. Fibrates in the prevention of cardiovascular events in dyslipidemic patients: a meta-analysis of randomized placebo-controlled clinical trials. J Am Coll Cardiol 2007;49(suppl A):abstract 1002-127.
  • Keech A., Simes RJ, Barter P. et al. Correction to the FIELD study report. Lancet 2006;368:1415.[Web of Science][Medline] [Order article via Infotrieve]
  • Ansquer JC, Foucher C., Rattier S. et al. Fenofibrate reduces progression to microalbuminuria over 3 years in a placebo-controlled study in type 2 diabetes: Results from the Diabetes Atherosclerosis Intervention Study (DAIS). Am J Kidney Dis 2005;45;485-93.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wierzbicki AS, Mikhailidis DP, Wray R. et al. Statin-fibrate combination therapy for hyperlipidaemia: a review. Curr Med Res Opin 2003;19:155-68.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ballantyne CM, Corsini A., Davidson MH et al. Risk of myopathy with statin therapy in high-risk patients. Arch Intern Med 2003;163:553-64.[Abstract/Free Full Text]
  • Rosenson RS Current overview of statin-induced myopathy. Am J Med 2004;116:408-16.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Alsheikh-Ali AA, Kuvin JT, Karas RH Risk of adverse events with fibrates. Am J Cardiol 2004;94:935-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Jones PH, Davidson MH Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin. Am J Cardiol 2005;95:120-2.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Prueksaritanont T., Subramanian R., Fang X. et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos 2002;30:505-12.[Abstract/Free Full Text]
  • Prueksaritanont T., Tang C., Qiu et al. Effects of fibrates on metabolism of statins in human hepatocytes. Drug Metab Dispos 2002;30:1280-7.[Abstract/Free Full Text]
  • Corsini A., Bellosta S., Davidson MH Pharmacokinetic interactions between statins and fibrates. Am J Cardiol 2005;96(suppl):44K-49K.[Web of Science][Medline] [Order article via Infotrieve]
  • ACCORD Study Group, Buse JB, Bigger JT, Byington RP Action to Control Cardiovascular Risk in Diabetes trial: design and methods. Am J Cardiol 2007;99:21i-33i.[Medline] [Order article via Infotrieve]

The British Journal of Diabetes & Vascular Disease, Vol. 8, No. 1, 22-27 (2008)
DOI: 10.1177/14746514080080010601
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This Article
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