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The British Journal of Diabetes & Vascular Disease
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Review: Microvascular complications: evaluation and monitoring relevance to clinical practice, clinical trials, and drug development

Adam Greenstein

Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester, M13 9NT, UK

Mitra Tavakoli

Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester, M13 9NT, UK

Moaz Mojaddidi

Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester, M13 9NT, UK

Ahmed Al-Sunni

Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester, M13 9NT, UK

Glenn Matfin

Division of Endocrinology and Diabetes, Department of Medicine, New York University School of Medicine, New York, USA

Rayaz A Malik

Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester, M13 9NT, UK, Rayaz.a.malik{at}man.ac.uk

The long-term microvascular complications of diabetes pose a major health burden. Although, much of the focus has been on the macrovascular much of the focus has been on the macrovascular complications, it is clear that the microvascular complications have a significant impact on both morbidity and mortality amongst diabetic patients. Indeed retinopathy, nephropathy, and neuropathy compete as the leading causes of premature blindness, end-stage renal disease, and non-traumatic lower-limb amputation, respectively. Furthermore, complications develop and progress in unison and indeed share many common risk factors. Effective evaluation and monitoring of these complications in clinical practice is clearly important, however, it is also relevant to clinical addressing microvascular complications, Novel intervention studies, and drug development programs diagnostic and therapeutic strategies are continually evolving in this area and will be discussed in more detail in this review.

Key Words: diagnosis • nephropathy • neuropathy • retinopathy • treatment.

References

The British Journal of Diabetes & Vascular Disease, Vol. 7, No. 4, 166-171 (2007)
DOI: 10.1177/14746514070070040501
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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Greenstein, A.
Right arrow Articles by Malik, R. A
Right arrow Search for Related Content
Social Bookmarking
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What's this?