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The British Journal of Diabetes & Vascular Disease
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Improving outcomes of pregnancy for women with type 1 and type 2 diabetes

Helen R Murphy

Department of Diabetes and Endocrinology, Ipswich Hospital NHS Trust, Heath Road, Ipswich, IP4 5PD, UK, Helen.Murphy{at}ipswichhospital.nhs.uk

Rosemary C Temple

Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital NHS Trust, Norwich, United Kingdom, NR4 7UY, UK

Jonathan M Roland

Peterborough and Stamford NHS Foundation Trust, Peterborough, PE3 6DA, UK

The pregnancy outcomes for women with type 1 diabetes remain poor with increased risk of major congenital malformation, stillbirth, premature delivery and perinatal death compared to the background maternity population. Despite clear evidence that women who attend prepregnancy care have improved blood glucose control with reduced risk of serious adverse outcomes, only a minority of women attend these clinics. For women with type 2 diabetes who are older, more obese and more likely to belong to an ethnic minority or live in an area of social deprivation, pregnancy outcomes are at least as poor as for women with type 1 diabetes. This is important as the prevalence of type 2 diabetes in women of reproductive years is increasing and even fewer women with type 2 diabetes attend prepregnancy care or take folic acid supplementation. Greater awareness regarding the risks among women with diabetes as well as primary and secondary healthcare professionals is required, if pregnancy outcomes are to be improved.

Key Words: prepregnancy care • pregnancy • type 1 diabetes • type 2 diabetes.

References

  • Confidential Enquiry into Maternal and Child Health. Pregnancy in women with type 1 and type 2 diabetes in 2002-03, England, Wales and Northern Ireland. London: CEMACH; 2005.
  • Macintosh MC, Fleming KM, Bailey JA et al. Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study. BMJ 2006;333:177.[Abstract/Free Full Text]
  • Miller E., Hare JW, Cloherty JP et al. Elevated maternal hemoglobin A1c in early pregnancy and major congenital anomalies in infants of diabetic mothers. N Engl J Med 1981;304:1331-4.[Web of Science][Medline] [Order article via Infotrieve]
  • Ylinen K., Aula P., Stenman UH, Kesaniemi-Kuokkanen T., Teramo K. Risk of minor and major fetal malformations in diabetics with high haemoglobin A1c values in early pregnancy. Br Med J (Clin Res Ed) 1984;289:345-6.[Medline] [Order article via Infotrieve]
  • Clausen TD, Mathiesen E., Ekbom P., Hellmuth E., Mandrup-Poulsen T., Damm P. Poor pregnancy outcome in women with type 2 diabetes. Diabetes Care 2005;28:323-8.[Abstract/Free Full Text]
  • McElduff A., Ross GP, Lagstrom JA et al. Pregestational diabetes and pregnancy: an Australian experience. Diabetes Care 2005;28:1260-1.[Free Full Text]
  • Dunne F., Brydon P., Smith K., Gee H. Pregnancy in women with type 2 diabetes: 12 years outcome data 1990-2002. Diabet Med 2003;20:734-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Roland JM, Murphy HR, Ball V., Northcote-Wright J., Temple RC The pregnancies of women with type 2 diabetes: poor outcomes but opportunities for improvement. Diabet Med 2005;22:1774-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Mills JL, Knopp RH, Simpson JL et al. Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis. N Engl J Med 1988;318:671-6.[Abstract]
  • Fuhrmann K., Reiher H., Semmler K., Fischer F., Fischer M., Glockner E. Prevention of congenital malformations in infants of insulin-dependent diabetic mothers. Diabetes Care 1983;6:219-23.[Abstract]
  • Fuhrmann K., Reiher H., Semmler K., Glockner E. The effect of intensified conventional insulin therapy before and during pregnancy on the malformation rate in offspring of diabetic mothers. Exp Clin Endocrinol 1984;83:173-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Jensen BM, Kuhl C., Molsted-Pedersen L., Saurbrey N., Fog-Pedersen J. Preconceptional treatment with insulin infusion pumps in insulin-dependent diabetic women with particular reference to prevention of congenital malformations. Acta Endocrinol Suppl (Copenh) 1986;277:81-5.[Medline] [Order article via Infotrieve]
  • Goldman JA, Dicker D., Feldberg D., Yeshaya A., Samuel N., Karp M. Pregnancy outcome in patients with insulin-dependent diabetes mellitus with preconceptional diabetic control: a comparative study. Am J Obstet Gynecol 1986;155:293-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Rowe BR, Rowbotham CJ, Barnett AH Pre-conception counselling, birth weight, and congenital abnormalities in established and gestational diabetic pregnancy. Diabetes Res 1987;6(1):33-5.[Web of Science][Medline] [Order article via Infotrieve]
  • 5. Damm P., Molsted-Pedersen L. Significant decrease in congenital malformations in newborn infants of an unselected population of diabetic women. Am J Obstet Gynecol 1989;161:1163-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Steel JM, Johnstone FD, Hepburn DA, Smith AF Can prepregnancy care of diabetic women reduce the risk of abnormal babies? BMJ 1990;301:1070-4.[Abstract/Free Full Text]
  • Kitzmiller JL, Gavin LA, Gin GD, Jovanovic-Peterson L., Main EK, Zigrang WD Preconception care of diabetes. Glycemic control prevents congenital anomalies. Jama 1991;265:731-6.[Abstract/Free Full Text]
  • Willhoite MB, Bennert HW, Jr., Palomaki GE et al. The impact of preconception counseling on pregnancy outcomes. The experience of the Maine Diabetes in Pregnancy Program. Diabetes Care 1993;16:450-5.[Abstract]
  • Cousins L., Kitzmiller J., Schneider J. et al. The California Diabetes and Pregnancy Program: implementation of a multicenter experience with diabetic pregnancies. J Perinatol 1992;12:173-80.[Medline] [Order article via Infotrieve]
  • Temple RC, Aldridge V., Murphy HR Prepregnancy care and pregnancy outcomes in women with type 1 diabetes. Diabetes Care 2006;29:1744-9.[Abstract/Free Full Text]
  • Temple R., Aldridge V., Greenwood R., Heyburn P., Sampson M., Stanley K. Association between outcome of pregnancy and glycaemic control in early pregnancy in type 1 diabetes: population based study. BMJ 2002;325:1275-6.[Free Full Text]
  • Ray JG, O'Brien TE, Chan WS Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a meta-analysis. QJM 2001;94:435-44.[Abstract/Free Full Text]
  • Gregory R., Tattersall RB Are diabetic pre-pregnancy clinics worth while? Lancet 1992;340:656-8.[CrossRef][Medline] [Order article via Infotrieve]
  • Holing EV, Beyer CS, Brown ZA, Connell FA Why don't women with diabetes plan their pregnancies? Diabetes Care 1998;21:889-95.[Abstract]
  • Janz NK, Herman WH, Becker MP et al. Diabetes and pregnancy. Factors associated with seeking pre-conception care. Diabetes Care 1995;18: 157-65.[Abstract]
  • Roland JM, Murphy HR, Ball V., Northcote-Wright T., Temple RC Type 2 diabetic pregnancies have a much worse outcome than type 1 pregnancies but with opportunities for improvement. Diabet Med 2005;In press.
  • Dunstan DW, Zimmet PZ, Welborn TA et al. The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 2002;25:829-34.[Abstract/Free Full Text]
  • Cundy T., Gamble G., Townend K., Henley PG, MacPherson P., Roberts AB Perinatal mortality in type 2 diabetes mellitus. Diabet Med 2000;17(1): 33-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Dunne F. Type 2 diabetes and pregnancy. Semin Fetal Neonatal Med 2005;10:333-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Farrell T., Neale L., Cundy T. Congenital anomalies in the offspring of women with type 1, type 2 and gestational diabetes. Diabet Med 2002; 19:322-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Cundy T., Slee F., Gamble G., Neale L. Hypertensive disorders of pregnancy in women with type 1 and type 2 diabetes. Diabet Med 2002;19:482-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Coetzee EJ, Jackson WP Oral hypoglycaemics in the first trimester and fetal outcome. S Afr Med J 1984;65:635-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Hellmuth E., Damm P., Molsted-Pedersen L. Congenital malformations in offspring of diabetic women treated with oral hypoglycaemic agents during embryogenesis. Diabet Med 1994;11:471-4.[Web of Science][Medline] [Order article via Infotrieve]
  • Glueck CJ, Wang P., Goldenberg N., Sieve-Smith L. Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod 2002;17:2858-64.[Abstract/Free Full Text]
  • Piacquadio K., Hollingsworth DR, Murphy H. Effects of in-utero exposure to oral hypoglycaemic drugs. Lancet 1991;338:866-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hughes RC, Rowan JA Pregnancy in women with type 2 diabetes: who takes metformin and what is the outcome? Diabet Med 2006;23:31822.
  • Hawthorne G. Metformin use and diabetic pregnancy-has its time come? Diabet Med 2006;23:223-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Simmons D., Walters BN, Rowan JA, McIntyre HD Metformin therapy and diabetes in pregnancy. Med J Aust 2004;180:462-4.[Web of Science][Medline] [Order article via Infotrieve]
  • Glueck CJ, Goldenberg N., Wang P., Loftspring M., Sherman A. Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy. Hum Reprod 2004;19:510-21.[Abstract/Free Full Text]
  • National Centre for Health Statistics. National Health Care Survey. In: www.cdcgoc/nchs/nhcshtm; 2006.
  • Friedman JM ACE inhibitors and congenital anomalies. N Engl J Med 2006;354:2498-500.[Free Full Text]
  • Cooper WO, Hernandez-Diaz S., Arbogast PG et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med 2006;354:2443-51.[Abstract/Free Full Text]
  • Friedman J., Polifka J. Teratogenic effects of drugs: a resource for clinicians (TERIS). Baltimore: Johns Hopkins University Press 2000.
  • Statins: beware during pregnancy. Prescrire Int 2006;15(81):18-19.[Medline] [Order article via Infotrieve]
  • Kenis I., Tartakover-Matalon S., Cherepnin N. et al. Simvastatin has deleterious effects on human first trimester placental explants. Hum Reprod 2005;20:2866-72.[Abstract/Free Full Text]

The British Journal of Diabetes & Vascular Disease, Vol. 7, No. 1, 38-42 (2007)
DOI: 10.1177/14746514070070010701


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