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The British Journal of Diabetes & Vascular Disease
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Treating resistant hypertension in type 2 diabetes: a role for spironolactone?

Adrian G Stanley

Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK, as90{at}le.ac.uk

Philip Swales

Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK

Herbert Thurston

Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK

Bryan Williams

Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK

References

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  • Johnston LC, Grieble HG Treatment of arterial hypertensive disease with diuretics. V. Spironolactone, an aldosterone antagonist. Arch Intern Med 1967;119:225-31.[Abstract/Free Full Text]
  • Clement DL Effect of spironolactone on systemic blood pressure, limb blood flow and response to sympathetic stimulation in hypertensive patients. Eur J Clin Pharmacol 1992;21:263-7.[CrossRef]
  • Henry M., Wehrlen M., Pelletier, Capron MH Spironolactone versus nifedipine in essential hypertension. Am J Cardiol 1990;65:36K-38K.[CrossRef][Medline] [Order article via Infotrieve]
  • Schohn DC, Spiesser R., Wehrlen M., Pelletier, Capron MH Aldactazine/captopril combination, safe and effective in mild to moderate systemic hypertension: report on a multicenter study of 967 patients. Am J Cardiol 1990;65:4K-6K.[CrossRef][Medline] [Order article via Infotrieve]
  • Williams B., Poulter NR, Brown MJ et al. British Hypertension Society. Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV. J Hum Hypertens 2004;18:139-85.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ouzan J., Pérault C., Lincoff M., Carré E., Mertes M. The role of spironolactone in the treatment of patients with refractory hypertension. Am J Hypertens 2002;15:333-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Brilla CG, Matsubara LS, Weber KT Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension. Am J Cardiol 1993;71:12A-16A.[CrossRef][Medline] [Order article via Infotrieve]
  • Falch DK, Schreiner A. The Effect of Spironolactone on Lipid, Glucose and Uric Acid Levels in Blood during Long-Term Administration to Hypertensives. Acta Med Scand 1983;213:27-30.[Web of Science][Medline] [Order article via Infotrieve]
  • Juurlink DN, Mamdani MM, Lee DS et al. Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study. N Engl J Med 2004;351:543-51.[Abstract/Free Full Text]
  • Winer BM, Lubbe WF, Colton T. Antihypertensive actions of diuretics. Comparative study of an aldosterone antagonist and a thiazide, alone and together. JAMA 1968;204:775-9.[Abstract/Free Full Text]
  • Large DM, Carr PH, Laing I., Davies M. Hyperkalaemia in diabetes mellitus - potential hazards of coexisting hyporeninaemic hypoaldosteronism. Postgrad Med J 1984;60:370-3.[Abstract/Free Full Text]

The British Journal of Diabetes & Vascular Disease, Vol. 6, No. 2, 90-92 (2006)
DOI: 10.1177/14746514060060020701


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This article has been cited by other articles:


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T. L. Goodfriend
Treating Resistant Hypertension With a Neglected Old Drug
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[Full Text] [PDF]


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