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Association of albuminuria with all-cause and cardiovascular disease mortality in diabetes: the Strong Heart Study

Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA, susan-xu{at}ouhsc.edu

Elisa T Lee

Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

Lyle G Best

Missouri Breaks Industries Research Inc, Timber Lake, SD, USA

Momotaz Begum

Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

William C Knowler

National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, AZ, USA

Richard R Fabsitz

National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

Barbara V Howard

Medstar Research Institute, Hyattsville, MD, USA

Objectives — To estimate the relative risks of albuminuria with all-cause and cardiovascular disease (CVD) mortality in a large cohort of American Indians with diabetes. Methods — A total of 1,953 diabetic participants in the Strong Heart Study were evaluated based on albuminuria categories at baseline examination. The Cox proportional hazards model was used to examine associations. Results — Of the 1,953 participants, 605 (31%) and 410 (21%) had microalbuminuria and macroalbuminuria, respectively, at baseline examination. Microalbuminuria (HR=1.42, 95% CI 1.15—1.77 for all-cause, and HR=1.48, CI 1.01—2.17 for CVD), and macroalbuminuria (HR=3.39, CI 2.71—4.25 for all-cause, and HR=3.74, CI 2.56—5.47 for CVD) were significant predictors for all-cause and CVD mortality after adjustment for other CVD risk factors. Conclusions — Results from the present study suggest that albuminuria is a strong independent predictor of all-cause and CVD Mortality in American Indians with diabetes.

Key Words: albuminuria • cardiovascular disease mortality • association • diabetes • American Indians.

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The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 6, 334-340 (2005)
DOI: 10.1177/14746514050050060701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Xu, J. Articles by Howard, B. V Search for Related Content Social Bookmarking                         What's this?