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The British Journal of Diabetes & Vascular Disease
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Fenofibrate in type 2 diabetes: The FIELD study

Fibrate Intervention and Event Lowering in Diabetes (FIELD)

Michael D Feher

Beta Cell Diabetes Centre, Chelsea & Westminster Hospital, London SW10 9NH, UK, michael.feher{at}chelwest.nhs.uk

Robert S Elkeles

Unit for Metabolic Medicine, St Marys Hospital, London, W2 1NY, UK

Key Words: fenofibrate • type 2 diabetes.

References

  • The FIELD study investigators. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005;366:1849-61.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Feher MD, Caslake M., Foxton J., Cox A., Packard CJ Atherogenic lipoprotein phenotype in type 2 diabetes: reversal with micronised fenofibrate. Diabetes Metab Res Rev 1999;15:395-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Diabetes Atherosclerosis Intervention Study Investigators. Effects of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 2001;357:905-10.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Madej A., Okopien B., Kowalski J. et al. Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinaemia IIB. Int J Clin Pharmacol Ther 1998;36:345-9.[Web of Science][Medline] [Order article via Infotrieve]
  • Keating GM, Ormrod D.: Micronised fenofibrate. An updated review of its clinical efficacy in the management of dyslipidaemia. Drugs 2002, 62:1909-44.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Turner RC, Millns H., Neil HA et al. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS 23). BMJ 1998;316:823-8.[Abstract/Free Full Text]
  • Colhoun HM, Betteridge DJ, Durrington PN et al. (Hitman GA, Neil HAW, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V. Fuller JH,) on behalf of the CARDS Investigators: Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004;364:685-96.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Collins R., Armitage J., Parish S. et al. for the Heart Protection Study Collaborative Group. MRC/BHF heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003;361:2005-16.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Rubins HB, Robins SJ, Collins D. et al. (Fye CL, Anderson JW, Elam BM, Faas FH, Linares E., Schaefer EJ, Schectman G., Wilt TJ, Wittes J.): Gemfibrozil for secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-density lipoprotein cholesterol Intervention Trial study group. N Engl J Med 1999;341:410-18.[Abstract/Free Full Text]
  • Davidson MH Combination therapy for dyslipidemia: safety and regulatory considerations. Am J Cardiol 2002;90:50K-60K.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Elkeles RS, Diamond JR, Poulter C. et al. Cardiovascular outcomes in type 2 diabetes. A double-blind placebo-controlled study of bezafibrate: the St. Mary's, Ealing, Northwick Park Diabetes Cardiovascular Disease Prevention (SENDCAP) Study. Diabetes Care 1998;21:641-8.[Abstract]
  • Frick MH, Elo O., Haapa K. et al. (Heinonen OP, Heinsalmi P, Helo P, Huttunen JK, Kaitaniemi P, Koskinen P, Manninen V and others): Helsinki Heart Study: primary prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety treatment, changes in risk factors and incidence of coronary heart disease. N Eng J Med 1987;317:1237-45.
  • Koskinen P., Mänttäri M., Manninen V., Huttunen JK, Heinonen OP, Frick MH: Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study. Diabetes Care 1992;15:820-5.[Abstract]
  • ACCORD - trial information for recruitment www.clinicaltrials.gov/ct/show/NCT00000620

The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 6, 330-333 (2005)
DOI: 10.1177/14746514050050060601


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