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Intima-media thickness and atherosclerotic plaques in popliteal, tibial, brachial and radial arteries in 65-year-old Finns with diabetes

Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, 90220 Oulu, Finland, ulla.rajala{at}oulu.fi

Markku Päivänsalo

Department of Diagnostic Radiology, University of Oulu, 90029 OYS, Finland

Mauri Laakso

Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, 90220 Oulu, Finland

Ilkka Suramo

Department of Diagnostic Radiology, University of Oulu, 90029 OYS, Finland

Sirkka Keinänen-Kiukaanniemi

Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, 90220 Oulu, Finland

The aim of the present study was to examine the intima-media thickness (IMT) and the number of atherosclerotic plaques in the medium-sized arteries of the lower and upper limbs in 65-year-old Finns (45 diabetic subjects, 65 subjects with impaired glucose tolerance [IGT] and 38 normoglycaemic [NGT] subjects). The maximal IMT of radial arteries was higher in subjects with diabetes (0.41 mm±0.07) than in those with IGT (0.36 mm±0.06) or NGT (0.35 mm±0.07) (p<0.001), but in popliteal, tibial and brachial arteries there were no significant differences between the groups. A large proportion of the study population had plaques in their lower limb arteries and some subjects had a very high number of plaques. The proportion of subjects with diabetes in the highest quintile of the number ( 79) of tibial plaques was 47%, while the corresponding number was 26% among those with a lower number of plaques (p=0.030). The occurrence of plaques in brachial and radial arteries was low. Diabetic subjects tended to have radial plaques more often than subjects with IGT and NGT.

Key Words: plaque • intima-media • popliteal • tibial • brachial • radial.

References

• American Diabetes Association. Peripheral arterial disease in people with diabetes. Diabetes Care 2003;26:3333-41.[Free Full Text]
• Hoogeveen EK, Kostense PJ, Jakobs C. et al. Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: The Horn Study. J Intern Med 2000;247:442-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Jude EB, Samson SO, Chalmers N., Boulton AJM. Peripheral arterial disease in diabetic and nondiabetic patients. Diabetes Care 2001;24:1433-7.[Abstract/Free Full Text]
• Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis. Epidemiology, pathophysiology, and management. JAMA 2002;287: 2570-81.[Abstract/Free Full Text]
• Rajala U., Laakso M., Päivänsalo M., Pelkonen O., Suramo I., KeinänenKiukaanniemi S. Low insulin sensitivity measured by both quantitative insulin sensitivity check index and homeostasis model assessment method as a risk factor of increased intima-media thickness of the carotid artery. J Clin Endocrinol Metab 2002;87:5092-7.[Abstract/Free Full Text]
• Rajala U., Päivänsalo M., Laakso M., Pelkonen O., Suramo I., KeinänenKiukaanniemi S. Associations of blood pressure with carotid intimamedia thickness in elderly Finns with diabetes mellitus or impaired glucose tolerance. J Human Hypertens 2003;17:705-11.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Rajala U., Päivänsalo M., Laakso M. et al. Lack of association between early atherosclerotic carotid artery wall lesions and serum level of homocysteine. Br J Diabetes Vasc Dis 2003;3:230-2.[Abstract/Free Full Text]
• Rajala U., Laakso M., Päivänsalo M., Suramo I., Keinänen-Kiukaanniemi S. Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance. J Human Hypertens 2005;19:85-91.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Rajala U., Keinänen-Kiukaanniemi S., Uusimäki A., Reijula K., Kivelä S.-L. Prevalence of diabetes mellitus and impaired glucose tolerance in a middle-aged Finnish population. Scand J Prim Health Care 1995;13:222-8.[Web of Science][Medline] [Order article via Infotrieve]
• Giral P., Pithois-Merli I., Filitti V. et al. Risk factors and early extracoronary atherosclerotic plaques detected by three-site ultrasound imaging in hypercholesterolemic men. Arch Intern Med 1991;51:950-6.
• O'Rourke MF, Hayward CS, Lehman ED Arterial stiffness. In: Hypertension: A companion to Brenner and Rector's The Kidney. Eds. Oparil S and Weber MA, WB Saunders Company 2000, p. 134-51.
• Niskanen L., Siitonen O., Suhonen M., Uusitupa MI Medial artery calcification predicts cardiovascular mortality in patients with NIDDM. Diabetes Care 1994;17:1252-6.[Abstract]
• Sucker C., Lanzer P. Arteriosclerosis and mediasclerosis: comparison of two vascular diseases associated with calcifications. Med Klin 2000;95: 207-10.[CrossRef][Web of Science]
• Bucciarelli P., Srámek A., Reiber JHC, Rosendaal FR Arterial intima-media thickness and its relationship with cardiovascualr disease and atherosclerosis: a possible contribution of medium-sized arteries. Thromb Haemost 2002;88:961-6.[Web of Science][Medline] [Order article via Infotrieve]

The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 5, 277-280 (2005)
DOI: 10.1177/14746514050050050701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Rajala, U. Articles by Keinänen-Kiukaanniemi, S. Search for Related Content Social Bookmarking                         What's this?