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Review: Insulin secretion: function and therapy of pancreatic beta-cells in diabetes

Oxford Centre for Diabetes, Endocrinology; and Metabolism, Churchill Hospital, University of Oxford, Oxford, OX3 7LJ, UK, patrik.rorsman{at}drl.ox.ac.uk

nsulin is secreted from the beta-cells of the pancreatic islets in response to an elevation of blood glucose concentration. This review describes a current view of the metabolic control of insulin secretion and the molecular mechanisms involved, including the role played by the beta-cell to ensure correct release of insulin as a result of electrical signals. It then considers what goes wrong in type 2 diabetes, a disease resulting from insufficient insulin secretion. It focuses on the influence of genetics exploring the theory of a genetic predisposition to type 2 diabetes, as well as the roles played by age and obesity. Finally, the mode of action of the hypoglycaemic sulphonylureas is discussed and the potential implications for the beta-cell associated with a sulphonylurea-based therapy.

Key Words: type 2 diabetes • insulin secretion • insulin resistance • beta-cell.

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The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 4, 187-191 (2005)
DOI: 10.1177/14746514050050040201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Rorsman, P. Search for Related Content Social Bookmarking                         What's this?