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The British Journal of Diabetes & Vascular Disease
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Comparison of three different definitions for the metabolic syndrome in non-diabetic Europeans

THE DECODE STUDY GROUP

Qing Qiao

Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland, qing.qiao{at}ktl.fi

Aim — To compare definitions for the metabolic syndrome given by the World Health Organization (WHO), the European Group for Study of Insulin Resistance (EGIR), and the National Cholesterol Education Program (NCEP). Study population — 4,190 men and 4,950 women from seven cross-sectional European studies. Results — The age-standardised prevalence of the metabolic syndrome by different definitions was 16.5—24.7% in men and 15.2—20.9% in women aged 30—77 years, and was lowest by the EGIR criteria. Subjects who met all three definitions accounted for only 31% of the men and 34% of the women who had the metabolic syndrome by any of the three definitions, whereas 37% of these men and 39% of these women met only one of the three. Subjects with the NCEP definition only were more obese, hypertensive and dyslipidaemic than those identified by other definitions. Conclusions — The prevalence of the metabolic syndrome is high in non-diabetic Europeans. The agreement between the three definitions in the identification of subjects with the metabolic syndrome is poor and the phenotypes of those identified differ.

Key Words: definitions • metabolic syndrome • insulin resistance.

References

  • Reaven GM Banting lecture 1988. Role of insulin resistance in human disease . Diabetes 1988;37:1595-607.[Abstract]
  • DeFronzo R., Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease . Diabetes Care 1991;14:173-94.[Abstract]
  • Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study . Am J Epidemiol 2002;156:1070-7.[Abstract/Free Full Text]
  • Stern MP, Williams K., Gonzalez-Villalpando C., Hunt KJ, Haffner SM Does the Metabolic Syndrome Improve Identification of Individuals at Risk of Type 2 Diabetes and/or Cardiovascular Disease? Diabetes Care 2004;27:2676-81.[Abstract/Free Full Text]
  • Lakka HM, Laaksonen DE, Lakka TA et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men . JAMA 2002;288:2709-16.[Abstract/Free Full Text]
  • Sattar N., Gaw A., Scherbakova O. et al. Metabolic Syndrome With and Without C-Reactive Protein as a Predictor of Coronary Heart Disease and Diabetes in the West of Scotland Coronary Prevention Study . Circulation 2003;108:414-19.[Abstract/Free Full Text]
  • Girman CJ, Rhodes T., Mercuri M. et al. The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)*1 . Am J Cardiol 2004;93:136-41.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hu G., Qiao Q., Tuomilehto J. et al. Prevalence of the Metabolic Syndrome and Its Relation to All-Cause and Cardiovascular Mortality in Nondiabetic European Men and Women . Arch Intern Med 2004;164:1066-76.[Abstract/Free Full Text]
  • Malik S., Wong ND, Franklin SS et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults . Circulation 2004;110:1245-50.[Abstract/Free Full Text]
  • Hunt KJ, Resendez RG, Williams K., Haffner SM, Stern MP National Cholesterol Education Program versus World Health Organization metabolic syndrome in relation to all-cause and cardiovascular mortality in the San Antonio Heart Study . Circulation 2004;110:1251-7.[Abstract/Free Full Text]
  • Alberti KG, Zimmet PZ Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation . Diabet Med 1998;15:539-53.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • WHO Consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Geneva: World Health Organisation; 1999. Report No.: 99.2.
  • Balkau B., Charles MA Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR) . Diabet Med 1999;16:442-3.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Expert Panel on Detection E, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) . JAMA 2001;285:2486-97.[Free Full Text]
  • Adult Treatment Panel III. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report . Circulation 2002;106:3143-421.[Free Full Text]
  • American College of Endocrinology Task Force on the Insulin Resistance Syndrome. American College of Endocrinology Position Statement on the Insulin Resistance Syndrome . Endocr Pract 2003;9:237-52.[Medline] [Order article via Infotrieve]
  • Grundy SM, Brewer HB, Jr., Cleeman JI, Smith SC, Jr., Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition . Arterioscler Thromb Vasc Biol 2004;24(2): e13-e18.[Free Full Text]
  • The DECODE Study Group. Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria . Arch Intern Med 2001;161:397-405.[Abstract/Free Full Text]
  • The DECODE Study Group. Age- and Sex-Specific Prevalences of Diabetes and Impaired Glucose Regulation in 13 European Cohorts . Diabetes Care 2003; 26(1):61-9.[Abstract/Free Full Text]
  • The DECODE Study Group. Will new diagnostic criteria for diabetes mellitus change phenotype of patients with diabetes? Reanalysis of European epidemiological data. DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group . BMJ 1998;317:371-5.[Abstract/Free Full Text]
  • Qiao Q., Hu G., Pyorala K. et al. The prevalence of the metabolic syndrome in Europe using four proposed definitions (Abstract). In: IDEG; 2003; Tours , France; 2003.
  • Alberti KG, Zimmet PZ Definition, Diagnosis and classification of Diabetes Mellitus and its Complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Geneva: World Health Organization. Department of Noncommunicable Disease Surveillance; 1999. Report No.: WHO/NCS/99.2.
  • Marchesini G., Forlani G., Cerrelli F. et al. WHO and ATPIII proposals for the definition of the metabolic syndrome in patients with Type 2 diabetes . Diabet Med 2004;21:383-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ford ES, Giles WH A comparison of the prevalence of the metabolic syndrome using two proposed definitions . Diabetes Care 2003;26:575-81.[Abstract/Free Full Text]
  • Jorgensen ME, Bjerregaard P., Gyntelberg F., Borch-Johnsen K. Prevalence of the metabolic syndrome among the Inuit in Greenland. A comparison between two proposed definitions . Diabet Med 2004;21:1237-42.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Balkau B., Charles MA, Drivsholm T. et al. Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome . Diabetes Metab 2002;28:364-76.[Web of Science][Medline] [Order article via Infotrieve]
  • Park YW, Zhu S., Palaniappan L., Heshka S., Carnethon MR, Heymsfield SB The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994 . Arch Intern Med 2003;163:427-36.[Abstract/Free Full Text]
  • Wang JJ, Hu G., Miettinen ME, Tuomilehto J. The metabolic syndrome and incident diabetes: assessment of four suggested definitions of the metabolic syndrome in a Chinese population with high post-prandial glucose . Horm Metab Res 2004;36:708-15.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Robbins DC, Andersen L., Bowsher R. et al. Report of the American Diabetes Association's Task Force on standardization of the insulin assay . Diabetes 1996;45:242-56.[Abstract]
  • Mooy JM, Grootenhuis PA, de Vries H. et al. Intra-individual variation of glucose, specific insulin and proinsulin concentrations measured by two oral glucose tolerance tests in a general Caucasian population: the Hoorn Study . Diabetologia 1996;39:298-305.[Web of Science][Medline] [Order article via Infotrieve]
  • The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up Report on the Diagnosis of Diabetes Mellitus . Diabetes Care 2003;26:3160-7.[Free Full Text]
  • Borch-Johnsen K., Colagiuri S., Balkau B. et al. Creating a pandemic of pre-diabetes: the proposed new diagnostic criteria for impaired fasting glycaemia . Diabetologia 2004;47:1396-402.[Web of Science][Medline] [Order article via Infotrieve]
  • Tan CE, Ma S., Wai D., Chew SK, Tai ES Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians? Diabetes Care 2004;27:1182-6.[Abstract/Free Full Text]
  • Oh JY, Hong YS, Sung YA, Barrett-Connor E. Prevalence and factor analysis of metabolic syndrome in an urban Korean population . Diabetes Care 2004;27:2027-32.[Abstract/Free Full Text]

The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 3, 161-168 (2005)
DOI: 10.1177/14746514050050030901
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