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The `polypill' to reduce cardiovascular risk: proof of concept

Data from the Steno-2 multifactorial intervention study in type 2 diabetes supports the `polypill' strategy to reduce cardiovascular risk

Warwick Medical School, Division of Medical Education, University of Warwick, Coventry, CV4 7AL, UK, vinod.patel{at}geh.nhs.uk

Oluf Pedersen

Steno Diabetes Center, Copenhagen, Denmark

John Morrissey

Diabetes and Endocrinology Centre, George Eliot Hospital NHS Trust, Nuneaton, England, UK

Hans-Henrik Parving

Steno Diabetes Center, Copenhagen, Denmark

Peter Gæde

Steno Diabetes Center, Copenhagen, Denmark

James Douglas Lee

Diabetes and Endocrinology Centre, George Eliot Hospital NHS Trust, Nuneaton, England, UK

This article considers data from the Steno-2 multifactorial intervention study in type 2 diabetes to which are applied the United Kingdom Prospective Diabetes Study (UKPDS) risk engine. Mathematical analyses support the use of a `polypill' to reduce cardiovascular risk in type 2 diabetes. It is suggested that the Polypill should include a statin, antihypertensive agents and aspirin.

Key Words: cardiovascular • type 2 diabetes • lipids • hypertension.

References

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• UKPDS Cardiac Risk calculator at dtu@ox.ac.uk
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• Jaiveer K., Saraswathy J., Lee JD, Morrissey J., Patel V. Can Steno-2 multifactorial intervention study and UKPDS standards be achieved in a District General Hospital in the UK? Diabetologia 2003;46:(suppl 2): A103.
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The British Journal of Diabetes & Vascular Disease, Vol. 4, No. 5, 339-341 (2004)
DOI: 10.1177/14746514040040051001


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Patel, V. Articles by Lee, J. D. Search for Related Content Social Bookmarking                         What's this?