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Assessment of postprandial glucose: relationship between a standardised continental breakfast and the oral glucose tolerance test

Service of Therapeutical Education for Chronic Diseases, University Geneva Hospital, Geneva, Switzerland, Alain.Golay{at}hcuge.ch

Christiane Guitard

Novartis Pharma AG, Basel, Switzerland

Monique Hoyer

Novartis Pharma AG, Basel, Switzerland

John O Logan

Novartis Pharma AG, Basel, Switzerland

Patrick C Brunel

Novartis Pharma AG, Basel, Switzerland

Background

To determine the relationship between postprandial glucose(PPG) and insulin values after an oral glucose tolerance test (OGTT) and a standardised continental breakfast.

Methods

An open, single-centre, randomised, crossover study in 32 fasted patients with type 2 diabetes and 10 healthy volunteers. Plasma glucose and insulin concentrations following a standardised breakfast challenge and a 75 g OGTT were measured over two hours.

Results

In both groups, the standardised breakfast induced similar plasma glucose and insulin profiles to the OGTT. Mean PPG excursions at each time-point were 1—2 mmol/L greater following the OGTT than the breakfast. Two-hour OGTT glucose levels correlated highly (r 0.80) with those following the breakfast at all time-points between 0.5—2 hours.

Conclusion

Plasma glucose levels measured 0.5—2 hours following a standardised breakfast are useful for assessing postprandial hyperglycaemia for diagnostic or post-treatment evaluations.

Key Words: OGTT • standardised breakfast challenge • post-prandial glucose evaluation.

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The British Journal of Diabetes & Vascular Disease, Vol. 4, No. 5, 321-324 (2004)
DOI: 10.1177/14746514040040050601


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Golay, A. Articles by Brunel, P. C Search for Related Content Social Bookmarking                         What's this?