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Low-dose statins: useful and safe?
Mike Schachter
Department of Clinical Pharmacology, National Heart and Lung Institute, Imperial College School of Medicine, St Marys Hospital, London, W2 1NY, UK, m.schachter{at}imperial.ac.uk
This article considers the raison d'être for the use of low-dose statins, their safety, efficacy and potential as non-prescription drugs. It is very much a personal contribution to a controversial area which has become very topical.
Key Words: statins low-dose primary prevention dyslipidaemia combination therapy.
References
- Leader. Don't restrict heart drugs to those who can pay for them. The Independent 13 May 2004.
- Editorial. OTC statins: a bad decision for public health. Lancet 2004; 363:1659.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Law MR, Wald NJ, Rudnicka AR Quantifying effects of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003;326:1423.[Abstract/Free Full Text]
- Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002;360:7-22.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Saku K., Sasaki J., Arakawa K. Low-dose effect of simvastatin (MK-733) on serum lipids, lipoproteins, and apolipoproteins in patients with hypercholesterolaemia. Clin Ther 1989;11:247-57.[Web of Science][Medline]
[Order article via Infotrieve]
- Lepre F., Nestel I., Clifton P., Lloyd B., Morgan T. Low-dose simvastatin in the treatment of mild to moderate hypercholesterolaemia. Clin Drug Invest 1997;13:237-41.
- Mabuchi H., Kita T., Matsuzaki M. et al. Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-doses simvastatin therapy in Japanese patients with hypercholesterolaemia and coronary heart disease. Circ J 2002;66:1096-100.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Farmer JA Learning from the cerivastatin experience. Lancet 2001;358: 1383-5.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Thompson PD, Clarkson P., Karas RH Statin-associated myopathy. JAMA 2003;289:1681-90.[Abstract/Free Full Text]
- Parra JL, Reddy KR Hepatotoxicity of hypolipidemic drugs. Clin Liver Dis 2003;7:415-33.[CrossRef][Medline]
[Order article via Infotrieve]
- Omar MA, Wilson JP FDA adverse event reports on statin-associated rhabdomyolysis. Pharmacother 2002;36:288-95.[CrossRef]
- Martin J., Krum H. Cytochrome P450 drug interactions within the HMG-CoA reductase inhibitor class: are they clinically relevant? Drug Saf 2003; 26:13-21.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Stein EA, Davidson MH, Dujovne CA et al. Efficacy and safety of low-dose simvastatin and niacin, alone and in combination, in patients with combined hyperlipidemia: a prospective trial. J Cardiovasc Pharmacol Ther 1996;1:107-16.[Abstract/Free Full Text]
- Vega GL, Ma PTS, Cater NB et al. Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndrome. Am J Cardiol 2003;91:956-60.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Nutescu EA, Shapiro NL Ezetimibe: a selective cholesterol absorption inhibitor. Pharmacotherapy 2003;23:1463-74.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Davidson MH, McGarry T., Bettis R. et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolaemia. J Am Coll Cardiol 2002;40:2125-34.[Abstract/Free Full Text]
- Cannon CP, Braunwald E., McCabe CH et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004;350:1495-504.[Abstract/Free Full Text]
- Williams B., Poulter NR, Brown MJ et al. British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary. BMJ 2004;328:634-40.[Free Full Text]
- Shepherd J. Statins for primary prevention: strategic options to save lives and money. J R Soc Med 2004;97:66-71.[Free Full Text]
The British Journal of Diabetes & Vascular Disease, Vol. 4, No. 4,
260-262 (2004)
DOI: 10.1177/14746514040040040801

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