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The British Journal of Diabetes & Vascular Disease
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Review: Lipid lowering drugs, inflammation and cardiovascular disease

Michael Schachter

Department of Clinical Pharmacology, National Heart and Lung Institute, Imperial College, St Mary's Hospital, London, W2 1NY, UK, m.schachter{at}ic.ac.uk

Inflammation is an integral part of atherosclerosis, both in its early phases and in acute coronary syndromes. Markers of inflammation, especially C-reactive protein (CRP) are increasingly recognised as predictors of cardiovascular events. At the same time, evidence is growing that the statins have anti-inflammatory properties which may at least in part be independent of their effect on lipids. Statins can rapidly lower levels of CRP and this may be paralleled by changes in cardiovascular risk which precede reductions in serum cholesterol levels. This therefore represents an additional rationale for the use of statins in cardiovascular disease prevention, both primary and secondary. It must be noted that the fibrates also possess anti-inflammatory activity, although by different mechanisms: this has not been explored to the same extent as is the case for the statins. Equally, the statins may ultimately be useful in other forms of chronic inflammatory disease.

Key Words: statins • inflammation • atherosclerosis • cardiovascular disease • C-reactive • protein.

References

The British Journal of Diabetes & Vascular Disease, Vol. 3, No. 3, 178-182 (2003)
DOI: 10.1177/14746514030030030401
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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Schachter, M.
Right arrow Search for Related Content
Social Bookmarking
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What's this?