Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
The British Journal of Diabetes & Vascular Disease
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Tesfaye, S.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Diabetic neuropathy: achieving best practice

Solomon Tesfaye

Tesfaye Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK, Solomon.Tesfaye{at}sth.nhs.uk

Peripheral neuropathy is one of the commonest complications of diabetes and the commonest form of neuropathy in the developed world.1 Diabetic polyneuropathy encompasses several neuropathic syndromes, and the commonest presentation is chronic distal symmetrical neuropathy (DSP). DSP, often associated with autonomic neuropathy, has two clinical consequences: namely neuropathic pain and foot ulceration. Both often occur in the same individual, and cause severe curtailment of quality of life. The other, less common presentations of diabetic polyneuropathy include acute painful neuropathies, and focal neuropathies (amyotrophy, pressure palsies, truncal radiculopathies, mononeuropathies and mononeuritis multiplex).2 Table 1 shows a recent classification of diabetic polyneuropathy based upon the natural history of the various syndromes.3

Key Words: diabetic neuropathy • diabetes • neuropathy • peripheral neuropathy • painful neuropathy • diabetic foot.

References

  • Tesfaye S., Stephens L., Stephenson J. et al. The prevalence of diabetic neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia 1996;39:1377-84.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Tesfaye S. Diabetic neuropathy. In: Wass JAH, Shallet SM (eds.). Oxford Textbook of Endocrinology Oxford: Oxford University Press, 2002:1789-98.
  • Watkins PJ, Edmonds ME Clinical features of diabetic neuropathy. In: Pickup J, Williams G (eds.). Textbook of Diabetes Vol. 2. Oxford: Blackwell Science, 1997;50.1-50.20.
  • Tesfaye S., Price D. Therapeutic approaches in diabetic neuropathy and neuropathic pain. In: Boulton AJM (ed.). Diabetic Neuropathy Carnforth: Marius Press, 1997:159-5.
  • Ewing DJ, Borsey DQ, Bellavere F., Clarke BF Cardiac autonomic neuropathy in diabetes: comparison of measures of R-R interval variation. Diabetologia 1981;21:18-24.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Andersen H., Jakobsen J. Motor function in diabetes. Diabetes Reviews 1999;7:326-41.[Web of Science]
  • Eaton SE, Harris ND, Rajbhandari SM et al. Spinal-cord involvement in diabetic neuropathy. Lancet 2001;358:35-6.[CrossRef][Medline] [Order article via Infotrieve]
  • Chan AW, MacFarlane IA, Bowsher DR, Wells JC, Bessex C., Griffiths K. Chronic pain in patients with diabetes mellitus: comparison with non-diabetic population. Pain Clin 1990;3:147-59.
  • Watkins PJ Pain and diabetic neuropathy. BMJ 1984;288:168-9.[Free Full Text]
  • Tesfaye S., Ward JD Clinical features of diabetic polyneuropathy. In: Veves A, (ed.). Clinical Management of Diabetic Neuropathy. Totowa NJ: Humana Press, 1998:49-60.
  • Tesfaye S., Watt J., Benbow SJ, Pang KA, Miles J., MacFarlane IA Electrical spinal cord stimulation for painful diabetic peripheral neuropathy. Lancet 1996;348:1696-701.
  • Boulton AJM. Foot problems in patients with diabetes mellitus. In: Pickup J, Williams G (eds.). Textbook of Diabetes Vol 2 Oxford: Blackwell Science, 1997:58.1-58.20.
  • Ward JD The diabetic leg. Diabetologia 1982;22:141-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ward JD, Simms JM, Knight G., Boulton AJM, Sandler DA Venous distension in the diabetic neuropathic foot (physical sign of arterio-venous shunting). J Roy Soc Med 1983;76:1011-14.[Abstract]
  • Rajbhandari SM, Jenkins R., Davies C., Tesfaye S. Charcot neuroarthropathy in diabetes mellitus. Diabetologia 2002;45:1085-96.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Caravati CM Insulin neuritis: a case report. Va Med Mon 1933;59:745-6.
  • Tesfaye S., Malik R., Harris N. et al. Arteriovenous shunting and proliferating new vessels in acute painful neuropathy of rapid glycaemic control (insulin neuritis). Diabetologia 1996;39:329-35.[Web of Science][Medline] [Order article via Infotrieve]
  • Archer AG, Watkins PJ, Thomas PJ, Sharma AK, Payan J. The natural history of acute painful neuropathy in diabetes mellitus. J Neurol Neorosurg Psychiatry 1983;46:491-6.
  • Boulton AJM, Armstrong WD, Scarpello JHB, Ward JD The natural history of painful diabetic neuropathy - a 4 year study. Postgrad Med J 1983;59:556-9.[Abstract/Free Full Text]
  • Benbow SJ, Chan AW, Bowsher D., McFarlane IA, Williams G. A prospective study of painful symptoms, small fibre function and peripheral vascular disease in chronic painful diabetic neuropathy. Diabet Med 1994; 11:17-21.[Medline] [Order article via Infotrieve]
  • Tesfaye S., Harris N., Wilson RM, Ward JD Exercise induced conduction velocity increment: a marker of impaired nerve blood flow in diabetic neuropathy. Diabetologia 1992;35:155-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Bastron JA, Thomas JE Diabetic polyradiculoneuropathy: clinical and electromyographic findings in 105 patients. Mayo Clinic Proc 1981;56: 725-32.[Web of Science][Medline] [Order article via Infotrieve]
  • Ellenberg M. Diabetic neuropathic cachexia. Diabetes 1974;23:418-23.[Web of Science][Medline] [Order article via Infotrieve]
  • Guy RJC, Clark CA, Malcolm PN, Watkins PJ Evaluation of thermal and vibration sensation in diabetic neuropathy. Diabetologia 1985;28:131.[Web of Science][Medline] [Order article via Infotrieve]
  • Eaton SEM, Tesfaye S. Clinical manifestations and measurement of somatic neuropathy. Diabetes Reviews 1999;7:312-25.[Web of Science]
  • Clements RS, Bell DSH. Diagnostic, pathogenic and therapeutic aspects of diabetic neuropathy. Special Topics Endocrinol Metab 1982;3:1-43.
  • Matikainen E., Juntunen J. Diabetic neuropathy: Epidemiological, pathogenetic, and clinical aspects with special emphasis on type 2 diabetes mellitus. Acta Endocrinol Suppl (Copenh) 1984;262:89-94.
  • Garland H. Diabetic amyotrophy. BMJ 1955;2:1287-90.[Free Full Text]
  • Coppack SW, Watkins PJ The natural history of femoral neuropathy. QJ Med 1991;79:307-13.[Abstract/Free Full Text]
  • Casey EB, Harrison MJG. Diabetic amyotrophy: a follow-up study. BMJ 1972;1:656.[Abstract/Free Full Text]
  • Garland H., Taverner D. Diabetic myelopathy. BMJ 1953;1:1405.[Free Full Text]
  • Subramony SH, Willbourn AJ Diabetic proximal neuropathy. Clinical and electromyographic studies. J Neurol Sci 1982;53:293-304.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ward JD Clinical features of diabetic neuropathy. In: Ward JD, Goto Y, (eds.). Diabetic Neuropathy. Chichester, UK: Wiley, 1990:281-96.
  • Leslie RDG, Ellis C. Clinical course following diabetic ocular palsy. Postgrad Med J 1978;54:791-2.[Abstract/Free Full Text]
  • Asbury AK, Aldredge H., Hershberg R., Fisher CM Oculomotor palsy in diabetes mellitus: a clinicopathological study. Brain 1970;93:555-7.[Free Full Text]
  • Zorilla E., Kozak GP Ophthalmoplegia in diabetes mellitus. Annals of Internal Medicine 1967;67:968-76.[Abstract/Free Full Text]
  • Goldstein JE, Cogan DG Diabetic ophthalmoplegia with special reference to the pupil. Arch Ophthalmol 1960;64:592-600.[Abstract/Free Full Text]
  • Ellenberg M. Diabetic truncal mononeuropathy - a new clinical syndrome. Diabetes Care 1978;1:10-13.[Abstract]
  • Boulton AJM, Angus E., Ayyar DR, Weiss R. Diabetic thoracic polyradiculopathy presenting as abdominal swelling. BMJ 1984;289:798-9.[Free Full Text]
  • Dyck PJ, Kratz KM, Karnes JL et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology 1993;43:817-24.[Abstract/Free Full Text]
  • Clayburgh RH, Beckenbaugh RD, Dobyns JH Carpal tunnel release in patients with diffuse peripheral neuropathy. J Hand Surg 1987;12A:380-3.[Medline] [Order article via Infotrieve]
  • White JES, Bullock RF, Hudgson P., Home PD, Gibson GJ Phrenic neuropathy in association with diabetes. Diabet Med 1992;9:954-6.[Web of Science][Medline] [Order article via Infotrieve]
  • Diabetes Control and Complications Trial Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy. Ann Int Med 1995;122:561-8.[Abstract/Free Full Text]
  • United Kingdom Prospective Diabetes Study Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 1998;352:837-53.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Boulton AJM, Drury J., Clarke B., Ward JD Continuous subcutaneous insulin infusion in the management of painful diabetic neuropathy. Diabetes Care 1982;5:386-90.[Abstract]
  • Max MB, Culnane M., Schafer SC et al. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987;37:589-96.[Abstract/Free Full Text]
  • Sindrup SH, Grodum E., Gram LF, Beck-Nielsen H. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Ther Drug Monit 1991;13:408-14.[Web of Science][Medline] [Order article via Infotrieve]
  • Davis JL Use of sibutramine hydrochloride monohydrate in the treatment of the painful peripheral neuropathy of diabetes. Diabetes Care 2000; 23:1594.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Rull J., Quibrera R., Gonzalez-Millan H., Lozano Castenada O. Symptomatic treatment of peripheral neuropathy with carbamazepine (Tegretol). Diabetologia 1969;5:215-18.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Chadda VS, Mathur MS Double blind study of the effects of diphenylhydrantoin sodium on diabetic neuropathy. J Assoc Physicians India 1978;26:403-06.[Medline] [Order article via Infotrieve]
  • Backonja M., Beydoun A., Edwards KR et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomised controlled trial. JAMA 1998;280:1831-6.[Abstract/Free Full Text]
  • Kastrup J., Angelo H., Petersen P., Dejgard A., Hilsted J. Treatment of chronic painful neuropathy with intravenous lidocaine infusion. BMJ 1986;292:173.[Free Full Text]
  • Capsaicin Study Group. The effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care 1992;15:159-65.[Abstract]
  • Zeigler D., Hanefeld M., Ruhnau KJ et al. Treatment of symptomatic diabetic peripheral neuropathy with anti-oxidant alpha-lipoic acid: a 3-week multicentre randomised controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Harati Y., Gooch C., Swenson M. et al. Double-blind randomised trial of tramadol for the treatment of the pain of diabetic neuropathy. Neuropathy 1998;50:1842-6.

The British Journal of Diabetes & Vascular Disease, Vol. 3, No. 2, 112-117 (2003)
DOI: 10.1177/14746514030030020601


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
British Journal of Diabetes & Vascular DiseaseHome page
D. T Williams, P. Price, and K. G Harding
Review: The clinical evaluation of lower limb perfusion in diabetic foot disease
The British Journal of Diabetes & Vascular Disease, November 1, 2003; 3(6): 394 - 398.
[Abstract] [PDF]


This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Tesfaye, S.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?