|
Sign In to gain access to subscriptions and/or personal tools.
|
Pre-diabetes: to treat or not to treat?
Ele Ferrannini
Department of Internal Medicine, Via Savi, 8, 56100 Pisa, Italy, ferranni{at}ifc.cnr.it
The prevalence of diabetes is increasing worldwide, bringing personal and economic burdens. Impaired glucose tolerance (IGT) generally precedes type 2 diabetes and strategies which target IGT and delay or prevent the onset of type 2 diabetes are being explored. IGT and type 2 diabetes are characterised by insulin resistance. Lifestyle and pharmacological approaches which ameliorate insulin resistance are being investigated as methods of diabetes prevention.
Key Words: IGT pre-diabetes diabetes prevention.
References
- International Diabetes Federation. Diabetes Atlas 2000.
- Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med 1997;14(suppl 5):S1-S85.[Medline]
[Order article via Infotrieve]
- Boyle JP, Honeycutt AA, Narayan KM et al. Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the U.S. Diabetes Care 2001;24:1936-40.[Abstract/Free Full Text]
- Mokdad AS, Ford EH, Bowman BA et al. Diabetes trends in the US: 1990-1998. Diabetes Care 2000;23:1278-83.[Abstract/Free Full Text]
- Paeratakul S., Lovejoy JC, Ryan DH, Bray GA The relation of gender, race and socioeconomic status to obesity and obesity comorbidities in a sample of US adults. Int J Obes Relat Metab Disord 2002;26:1205-10.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Swinburn BA, Metcalf PA, Ley SJ Long-term (5-year) effects of a reduced-fat diet intervention in individuals with glucose intolerance. Diabetes Care 2001;24:619-24.[Abstract/Free Full Text]
- Hu FB, Leitzmann MF, Stampfer MJ et al. Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med 2001;161:1542-8.[Abstract/Free Full Text]
- Burrows NR, Geiss LS, Engelgau MM, Acton KJ Prevalence of diabetes among Native Americans and Alaska Natives, 1990-1997: an increasing burden. Diabetes Care 2000;23:1278-83.[Abstract/Free Full Text]
- Lorenzo C., Serrano-Rios M., Martinez-Larrad MT et al. Was the historic contribution of Spain to the Mexican gene pool partially responsible for the higher prevalence of type 2 diabetes in Mexican-origin populations? The Spanish Insulin Resistance Study Group, the San Antonio Heart Study, and the Mexico City Diabetes Study. Diabetes Care 2001;24: 2059-64.[Abstract/Free Full Text]
- Burden AC Blood pressure control and cardiovascular risk in patients of Indo-Asian and African-Caribbean descent. Int J Clin Pract 1998;52: 388-94.[Web of Science][Medline]
[Order article via Infotrieve]
- Abate N., Chandalia M. Ethnicity and type 2 diabetes: focus on Asian Indians. J Diabetes Complications 2001;15:320-7.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Aschner P. Diabetes trends in Latin America. Diabetes Metab Res Rev 2002;18(suppl 3):S27-S31.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Skyler JS, Oddo C. Diabetes trends in the USA. Diabetes Metab Res Rev 2002;18(suppl 3):S21-S26.
- Bagust A., Hopkinson PK, Maier W., Currie CJ An economic model of the long-term health care burden of type II diabetes. Diabetologia 2001;44:2140-55.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Bagust A., Hopkinson PK, Maslove L., Currie CJ The projected health care burden of Type 2 diabetes in the UK from 2000 to 2060. Diabet Med 2002;19(suppl 4):1-5.[Web of Science][Medline]
[Order article via Infotrieve]
- Gray A., Raikou M., McGuire A. et al. Cost effectiveness of an intensive blood glucose control policy in patients with type 2 diabetes: economic analysis alongside randomised controlled trial (UKPDS 41). BMJ 2000; 320:1373-8.[Abstract/Free Full Text]
- Clarke P., Gray A., Adler A. et al. Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with type II diabetes (UKPDS No. 51). Diabetologia 2001;44:298-304.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- UK Prospective Diabetes Study Group. Intensive blood glucose control with sulphonylurea or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- DeFronzo RA, Bonnadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 1992;15:318-68.[Abstract]
- DeFronzo RA Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis. Neth J Med 1997;50:191-7.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Köhler C., Henkel E., Temelkova-Kurktschiev T. et al. Incidence of impaired fasting glucose, impaired glucose tolerance and type 2 diabetes in a German risk population: the RIAD study. Diabetologia 2001; 44(suppl 1):A108.[CrossRef]
- American Diabetes Association. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183-97.[Web of Science][Medline]
[Order article via Infotrieve]
- Lim SC, Tai ES, Tan BY, Chew SK, Tan CE Cardiovascular risk profile in individuals with borderline glycemia: the effect of the 1997 American Diabetes Association diagnostic criteria and the 1998 World Health Organization Provisional Report. Diabetes Care 2000;23:278-82.[Abstract]
- Temelkova-Kurktschiev T., Siegert G., Bergmann S. et al. Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes. Metabolism 2002;51:743-9.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Hanefeld M., Köhler C., Henkel E. Post-challenge hyperglycaemia relates more strongly than fasting hyperglycaemia with carotid intimamedia thickness: the RIAD Study. Risk factors in impaired glucose tolerance for atherosclerosis and diabetes. Diabet Med 2000;17:835-40.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Saydah SH, Miret M., Sung J., Varas C., Gause D., Brancati FL Postchallenge hyperglycemia and mortality in a national sample of U.S. adults. Diabetes Care 2001;24:1397-402.[Abstract/Free Full Text]
- Tuomilehto J., Lindstrom J., Eriksson JG et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-50.[Abstract/Free Full Text]
- Pan XR, Li GW, Hu YH et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care 1997;20:537-44.[Abstract]
- Wenying Y., Lixiang L., Jinwu Q., Guangwei L., Zhiqing Y., Xiaoren P. The preventive effect of acarbose and metformin on the IGT population from becoming diabetes mellitus: a 3-year multicentral prospective study. Chin J Endocrinol Metab 2001;17:131-4.
- Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403.[Abstract/Free Full Text]
- Chiasson J-L., Josse RG, Gomis R., Hanefeld M., Karasik A., Laakso M. Acarbose can prevent the progression of impaired glucose tolerance to type 2 diabetes mellitus: results of a randomised clinical trial: the STOP-NIDDM trial. Lancet 2002;359:2072-7[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
The British Journal of Diabetes & Vascular Disease, Vol. 3, No. 1 suppl,
S2-S5 (2003)
DOI: 10.1177/14746514030030010201

CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?
|
|