|
Sign In to gain access to subscriptions and/or personal tools.
|
Is there any conclusive evidence that exercise alone reduces glucose intolerance?
Arne Astrup
Department of Human Nutrition, RVA University, 30 Rolighedsvej, 1958 Frederiksberg C, Copenhagen, Denmark, ast{at}kvl.dk
Physical activity improves insulin sensitivity and glucose metabolism, although such effects are short-lasting and regular exercise is needed to sustain them. Weight loss, especially loss of visceral fat, appears to be especially important in improving metabolic function and clinical outcomes. The most important consequences of exercise are probably promotion of weight loss and prevention of weight gain. Substantial weight losses, associated with significant improvements in glycaemic control and reductions in the incidence of type 2 diabetes, have been observed in intervention studies in overweight or obese subjects. These benefits were achieved using intensive lifestyle interventions, pharmacotherapy or surgery. Thus, programmes of diet and exercise aimed at achieving control of body weight should play a central role in strategies for diabetes prevention.
Key Words: weight loss diabetes prevention obesity diet exercise.
References
- Pan XR, Li GW, Hu YH et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 1997;20:537-44.[Abstract]
- Tuomilehto J., Lindstrom J., Eriksson JG et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-50.[Abstract/Free Full Text]
- Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403.[Abstract/Free Full Text]
- Wannamethee GS, Shaper GA, Alberti G. Physical activity, metabolic factors, and the incidence of coronary heart disease and type 2 diabetes. Arch Intern Med 2000;160:2108-16.[Abstract/Free Full Text]
- Wei M., Gibbons LW, Mitchell TL et al. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 1999;130:89-96.[Abstract/Free Full Text]
- Hu F., Manson JE, Meir J. et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001;345:790-7.[Abstract/Free Full Text]
- Colditz GA, Willett WC, Rotnitzky A., Manson JE Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 1995; 122:481-6.[Abstract/Free Full Text]
- Prentice AM, Jebb SA Beyond body mass index. Obes Rev 2001; 2:141-7.[CrossRef][Medline]
[Order article via Infotrieve]
- Astrup A., Eiberg C., Klausen C., Lerche-Black E. Is BMI invalid as a measure of obesity? Int J Obes Relat Metab Disord 2002;26(suppl 1):S70.
- Goodpaster BH, Kelley DE, Wing RR et al. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 1999;48:839-47.[Abstract]
- Bosello O., Armellini F., Zamboni M., Fitchet M. The benefits of modest weight loss in type II diabetes. Int J Obes Relat Metab Disord 1997;21 (suppl 1):S10-S30.[Web of Science]
- Campbell PJ, Gerich JE Impact of obesity on insulin action in volunteers with normal glucose tolerance: demonstration of a threshold for the adverse effect of obesity. J Clin Endocrinol Metab 1990;70:1114-18. 13. Zamboni M., Armellini F., Turcato E. et al. Relationship between visceral fat, steroid hormones and insulin sensitivity in premenopausal obese women. J Intern Med 1994;236:521-7.[Web of Science][Medline]
[Order article via Infotrieve]
- Buemann B., Black E., Holst C. et al. Insulin sensitivity is associated with aerobic capacity independently of body fat in overweight men. Int J Obes Relat Metab Disord 2002;26(suppl 1):S21.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Rice B., Janssen I., Hudson R., Ross R. Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care 1999;22:684-1.[Abstract/Free Full Text]
- Ross R., Dagnone D., Jones PJ et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exerciseinduced weight loss in men. A randomised, controlled trial. Ann Intern Med 2000;133:92-103.
- Sjöström CD, Lissner L., Wedel H., Sjostrom L. Reduction in incidence of diabetes, hypertension and lipid disturbances after intentional weight loss induced by bariatric surgery: the SOS Intervention Study. Obes Res 1999;7:477-84.[Web of Science][Medline]
[Order article via Infotrieve]
- Sjöström L. Surgical outcomes from the SOS study. IJO 2002;26(suppl 1):825.
- Finer N., Bloom SR, Frost GS et al. Sibutramine is effective for weight loss and diabetic control in obesity with type 2 diabetes: a randomised, double-blind, placebo-controlled study. Diabetes Obes Metab 2000;2:105-12.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Fujioka K., Seaton TB, Rowe E. et al. Weight loss with sibutramine improves glycaemic control and other metabolic parameters in obese patients with type 2 diabetes mellitus. Diabetes Obes Metab 2000;2: 175-87.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Hollander PA, Elbein SC, Hirsch IB et al. Role of orlistat in the treatment of obese patients with type 2 diabetes. A 1-year randomised double-blind study. Diabetes Care 1998;21:1288-94.[Abstract]
- Heymsfield SB, Segal KR, Hauptman J. et al. Effects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults. Arch Intern Med 2000;160:1321-6.[Abstract/Free Full Text]
- Torgerson JS, Arlinger K., Kappi M., Sjostrom L. Principles for enhanced recruitment of subjects in a large clinical trial. The XENDOS (XENical in the prevention of Diabetes in Obese Subjects) study experience. Control Clin Trials 2001;22:515-25.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
The British Journal of Diabetes & Vascular Disease, Vol. 3, No. 1 suppl,
S18-S23 (2003)
DOI: 10.1177/14746514030030010501

CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?
|
|