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The British Journal of Diabetes & Vascular Disease
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Reviews

Review: Thirty-seven years with diabetic retinopathy

Eva M Kohner

Department of Medicine, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK, e.kohner{at}kcl.ac.uk

Diabetic retinopathy was rare 50 years ago. Since then it has become the commonest cause of visual loss in the working age population. Initially the only treatment available was pituitary ablation, and that only worked for some patients with proliferative retinopathy. In the 1970s laser treatment revolutionised the management of retinopathy. Improvements in the assessment and management of retinopathy stimulated research with controlled clinical trials. This has resulted in evidence-based recommendations for improvement in glucose and blood pressure control which has been shown to reduce the prevalence of retinopathy. Screening procedures are now available for most people with diabetes. New treatments under development, directed at the pathogenic mechanisms of retinopathy, offer hope that the laser will eventually be replaced by more effective and better tolerated treatment.

Key Words: diabetic retinopathy • pituitary ablation • photocoagulation • screening • photographic grading.

References

  • Ballantyne AJ, Loewenstein A. The pathology of diabetic retinopathy. Trans Ophthal Soc UK 1943;63:95-115.
  • Scott GI Ocular complications of diabetes mellitus. Br J Ophthalmol 1953;37:705-12.[Free Full Text]
  • Poulsen JE Recovery from retinopathy in a case of diabetes with Simmond's disease. Diabetes 1953;2:7-12.[Medline] [Order article via Infotrieve]
  • Joplin JF, Oakley NW, Kohner EM, Hill DW, Fraser TR Diabetic retinopathy II: The effect of different degrees of Pituitary ablation on diabetic retinopathy. Diabetologia 1967;3:406-12.[CrossRef][Medline] [Order article via Infotrieve]
  • Wright AD, Kohner EM, Oakley NW, Fraser TR, Joplin GF, Hartog M. Serum growth hormone levels and the response of diabetic retinopathy to pituitary ablation. BMJ 1969;2:346-8.[Abstract/Free Full Text]
  • Kohner EM, Dollery CT, Bulpitt CJ Cotton wool spots in diabetic retinopathy. Diabetes 1971;20:816-23.[Medline] [Order article via Infotrieve]
  • Kohner EM, Pannisett A., Cheng H., Fraser TR Diabetic retinopathy: New vessels arising from the optic disc, grading system and natural history. Diabetes 1971;20:816-23.[Medline] [Order article via Infotrieve]
  • Kohner EM, Dollery CT, Paterson JW, Oakley NW Arterial fluorescein studies in diabetic retinopathy. Diabetes 1967;16:1-10.[Medline] [Order article via Infotrieve]
  • Oakley NW, Hill DW, Joplin GF, Kohner EM, Fraser TR Diabetic retinopathy I. The assessment of severity and progression by comparison with a set of standard fundus photographs. Diabetologia 1967;3:402-05.[CrossRef][Medline] [Order article via Infotrieve]
  • The Treatment of Diabetic Retinopathy Airlie House Symposium. Ed. Goldberg MF and Fine SL. Pub. US Dept. of Health Education and Welfare 1969.
  • Klein BEK, Davis MD, Segal P., Klein R. Diabetic retinopathy: assessment of severity and progression. Ophthalmology 1984;91:10-17.[Web of Science][Medline] [Order article via Infotrieve]
  • Diabetic Retinopathy Study Research Group Preliminary report on the effects of photocoagulation treatment. Am J Ophthalmol 1976;81:383-96.[Web of Science][Medline] [Order article via Infotrieve]
  • British Multicenter Study Group. Proliferative diabetic retinopathy: treatment with xenon arc photocoagulation. BMJ 1977;1:739-42.[Abstract/Free Full Text]
  • Cheng H., Kohner EM, Keen H. and the Multicentre Study Group. Photocoagulation in diabetic maculopathy. Lancet 1975;2:1110-13.[CrossRef][Medline] [Order article via Infotrieve]
  • Early Treatment of Diabetic Retinopathy Study Group. Photocoagulation for diabetic macular oedema. Arch Ophthalmol 1982;103:1796-806.
  • The Diabetic Retinopathy Vitrectomy Study Research Group. Early vitrectomy for severe proliferative diabetic retinopathy in eyes with useful vision. Ophthalmology 1988;95:1307-20.[Web of Science][Medline] [Order article via Infotrieve]
  • The DAMAD Study Group. Effect of aspirin alone and aspirin and dipyramidole in early diabetic retinopathy: Multicentre randomised controlled clinical trial. Diabetes 1989;38:491-8.[Abstract]
  • Sorbinil Trial Research Group. A randomised trial of Sorbinil, an aldose reductase inhibitor on diabetic retinopathy. Arch Ophthalmol 1990;108:1234-8.[Abstract/Free Full Text]
  • Pickup JC, White MC, Keen H., Kohner EM, Parsons JA, Alberti Kgmm. Long term continuous subcutaneous insulin infusion in diabetes at home. Lancet 1979;2:870-3.[Web of Science][Medline] [Order article via Infotrieve]
  • Lauritzen T., Frost-larsen K., Larsen HW, Deckert T. Effect of one year near normal blood glucose levels on retinopathy in insulin dependent diabetics. Lancet 1983;1:200-04.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • The Kroc Collaborative Study Group. Blood glucose control and the evolution of diabetic retinopathy and albuminuria. N Engl J Med 1984; 311:365-72.[Abstract]
  • Dahl-Jorgensen K., Brinchmann-Hansen O., Hanssen KF, Bangstad HJ Blood glucose control and diabetic microvascular complications: long term effects of near-normo-glycaemia. Diabetic Med 1992;9:697-805.[Web of Science][Medline] [Order article via Infotrieve]
  • Chantelau E. What may be gained from standard photocoagulation during early worsening of retinopathy? Diabetes et Metab (Paris) 2001;27:366-71.
  • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin dependent diabetes mellitus. N Engl J Med 1993;329:977-86.[Abstract/Free Full Text]
  • Early Treatment of Diabetic Retinopathy Study Group (10). Grading diabetic retinopathy from stereoscopic colour fundus photography; and extension of the modified Airlie House classification. Ophthalmology 1991;98:786-806.[Web of Science][Medline] [Order article via Infotrieve]
  • UK Prospective Study Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • UK Prospective Study Group. Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • UK Prospective Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes (UKPDS 38). BMJ 1998;317:703-13.[Abstract/Free Full Text]
  • UK Prospective Study Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications of type 2 diabetes (UKPDS 39). BMJ 1998;317:713-20.[Abstract/Free Full Text]
  • International Group. Diabetes care and research in Europe: The St Vincent Declaration. Diabetic Medicine 1990;7:360-80.[Web of Science][Medline] [Order article via Infotrieve]
  • Kohner EM, Stratton IM, Aldington SJ, Holman RR, Matthews DR Relationship between the severity of retinopathy and progression to photocoagulation in patients with type 2 diabetes in the UKPDS (UKPDS 52). Diabet Med 2001;18:178-84.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Agardh E., Agardh CD, Hanson-Lundbland C. The 5-year incidence of blindness after introducing screening programme for early detection of treatable diabetic retinopathy. Diabet Med 1993;10:555-9.[Web of Science][Medline] [Order article via Infotrieve]
  • Chaturvedi N., Sjolie AK, Stephenson JM Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes: The EUCLID Study. Lancet 1998;357:28-31.
  • Aiello LP, Avery RL, Arigg PG Vascular Endothelial Growth Factor inocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994;331:1480-7.[Abstract/Free Full Text]
  • Aiello LP, Bursell SE, Clermont A. Vascular endothelial growth factor induced retinal permeability is mediated by protein kinase C in vivo and supressed by an orally effective B isoform selective inhibitor. Diabetes 1997;46:1473-80.[Abstract]
  • Chibber R., Ben-Mahmud BM, Mann G., Kohner EM Submitted for publication.

The British Journal of Diabetes & Vascular Disease, Vol. 2, No. 6, 452-456 (2002)
DOI: 10.1177/14746514020020060701


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This Article
Right arrow Abstract Freely available
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Right arrow Alert me when this article is cited
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Right arrow Citing Articles via Google Scholar
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 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?