This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gale, E. A. Search for Related Content Social Bookmarking                         What's this?

Review: Fifty years of type 1 diabetes

Division of Medicine, Diabetes and Metabolism, Medical School Unit, Southmead Hospital, Bristol, BS10 5NB, UK, Edwin.Gale{at}bristol.ac.uk

Research is done by people. Type 1 diabetes was discovered because certain people were in certain places at the right time. Perhaps in a parallel universe someone else would have made the same observations or reached the same insights, but that is not what happened here. It has been my privilege to know many of the people concerned with the discovery, and this is my version of what they achieved.

Key Words: type 1 diabetes • history • HLA • islet cell antibodies.

References

• Himsworth HP Diabetes mellitus. Its differentiation into insulin-sensitive and insulin-insensitive types. Lancet 1936;i:127-30.
• Draper G., Dupurtuis CW, Caughey JL The differentiation by constitutional methods between pancreatic diabetes and diabetes of pituitary origin. Trans Am Assoc Phys 1940;55:146-53.
• Draper G., Dupurtuis CW, Caughey JL Human constitution in clinical medicine. New York: Harper, 1944.
• Lister J., Nash J., Ledingham U. Constitution and insulin sensitivity in diabetes mellitus. BMJ 1951;i:376-9.
• Tattersall RB, Pyke DA Diabetes in identical twins. Lancet 1972;ii:1120-5.
• Nerup J., Platz P., Andersen O. et al. HL-A antigens and diabetes mellitus. Lancet 1974;ii:864-6.
• Cudworth AG, Woodrow JC HL-A antigens and diabetes mellitus. Lancet 1974;ii:1153.
• Bottazzo GF, Florin-Christensen A., Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974;ii: 1280-3.
• MacCuish AC, Barnes EW, Irvine WJ, Duncan LJP. Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease. Lancet 1974;ii:1529-31.
• Cudworth AG The aetiology of diabetes mellitus. Br J Hosp Med 1976;16:207-16.
• Gale EAM. The discovery of type 1 diabetes. Diabetes 2001;50:217-26.[Medline] [Order article via Infotrieve]

The British Journal of Diabetes & Vascular Disease, Vol. 2, No. 6, 441-445 (2002)
DOI: 10.1177/14746514020020060501


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gale, E. A. Search for Related Content Social Bookmarking                         What's this?