Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
The British Journal of Diabetes & Vascular Disease
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Owens, D. R.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Optimising glycaemic control — the role of long-acting insulin analogues in basal insulin therapy

David Raymond Owens

Diabetes Research Unit, Llandough Hospital, Penarth, Wales, owensdr{at}cf.ac.uk

Current insulin treatment regimens effectively combat post-prandial hyperglycaemia, but are unable to reinstate normal fasting plasma glucose concentrations. The advent of long-acting soluble insulin analogues, such as insulin glargine and insulin detemir, offers improved control of basal hyperglycaemia without increasing the risk of hypoglycaemia.

Key Words: glycaemic control • insulin treatment • basal insulin • insulin analogues • insulin glargine • insulin detemir.

References

  • Owens DR, Zinman B., Bolli GB Insulins today and beyond. Lancet 2001; 358:739-46.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-86.[Abstract/Free Full Text]
  • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group. Effect of intensive diabetes treatment on carotid artery wall thickness in the epidemiology of diabetes interventions and complications. Diabetes 1999;48:383-90.[Abstract]
  • Lepore M., Pampanelli S., Fanelli CG et al. Pharmacokinetics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, ultralente human insulin, and continuous subcutaneous infusion of insulin lispro. Diabetes 2000;49:2142-8.[Abstract/Free Full Text]
  • Heinemann L., Weyer C., Rauhaus M., Heinrichs S., Heise T. Variability of the metabolic effect of soluble insulin and the rapid-acting insulin analog insulin aspart. Diabetes Care 1998;21:1910-14.[Abstract]
  • Rosskamp RH, Park G. Long-acting insulin analogs. Diabetes Care 1999; 22(suppl 2):B109-13.[Web of Science][Medline] [Order article via Infotrieve]
  • Koivisto VA The human insulin analogue insulin lispro. Ann Med 1998; 30:260-6.[Web of Science][Medline] [Order article via Infotrieve]
  • Simpson KL, Spencer CM Insulin aspart. Drugs 1999;57:759-65.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Bolli GB, Owens DR Insulin glargine. Lancet 2000;356:443-5.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • McKeague K., Goa KL Insulin glargine. A review of its therapeutic use as a long-acting agent for the management of type 1 and 2 diabetes mellitus. Drugs 2001;61:1599-624.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pieber TP, Eugene-Jolcine I., Derobert E. Efficacy and safety of HOE 901 versus NPH insulin in patients with type 1 diabetes. Diabetes Care 2000; 23:157-62.[Abstract]
  • Rosenstock J., Park G., Zimmerman J. Basal Insulin Glargine (HOE 901) versus NPH insulin in patients with type 1 diabetes on multiple daily insulin regimens. US Insulin Glargine (HOE 901) Type 1 Diabetes Investigator Group. Diabetes Care 2000;23:1137-42.[Abstract/Free Full Text]
  • Hershon K., Blevins T., Donley D., Littlejohn C. Lower fasting blood glucose (FBG) and less symptomatic hypoglycemia with QD insulin glargine (Lantus) compared to BID NPH in subjects with type 1 diabetes [abstract]. Diabetes 2001;50(suppl 2):116-17.
  • Ratner RE, Hirsch IB, Neifing JL, Garg SK, Mecca TE, Wilson CA Less hypoglycaemia with insulin glargine in intensive insulin therapy for type 1 diabetes. US Study Group of Insulin Glargine in Type 1 Diabetes. Diabetes Care 2000;23:639-43.[Abstract/Free Full Text]
  • Standl E. Results of an international, multicentred, randomised, 28 week study for the comparison of glargine insulin (HOE 901) and NPH insulin in the intensified treatment (ICT) of type 1 diabetics [abstract]. Exp Clin Endocrinol Diabetes 2000;108(suppl 1):159.
  • Raskin P., Klaff L., Bergenstal R., Halle JP, Donley D., Mecca T. A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes. Diabetes Care 2000;23:1666-71.[Abstract/Free Full Text]
  • Schoenle E. Insulin glargine (HOE 901) lowers fasting blood glucose in children with type 1 diabetes mellitus without increasing the risk of hypoglycaemia [abstract]. Diabetologia 1999;42(suppl 1):A235.
  • Matthews DR, Pfeiffer C. Comparative clinical trial of a new long-acting insulin (HOE 901) vs protamine insulin demonstrates less nocturnal hypoglycaemia. Multicentre HOE 901 Research Group [abstract]. Diabetes 1998;47(suppl 1):A101.
  • Raskin P., Park G., Zimmerman J. The effect of HOE 901 on glycaemic control in type 2 diabetes [abstract]. Diabetes 1998;47(suppl 1):A103.
  • Rosenstock J., Schwartz SL, Clark CM Jr, Park GD, Donley DW, Edwards MB Basal insulin therapy in type 2 diabetes: 28-week comparison of insulin glargine (HOE 901) and NPH insulin. Diabetes Care 2001;24:631-6.[Abstract/Free Full Text]
  • Fonseca V., Bell D., Mecca T. Less symptomatic hypoglycaemia with bedtime insulin glargine (Lantus) compared to bedtime NPH insulin in patients with type 2 diabetes [abstract]. Diabetes 2001;50(suppl 2):112-13.
  • Massi Benedetti M. Results of a 12-month study: insulin glargine (HOE 901) in combination with oral agents [abstract]. 35th Annual Meeting of the European Association for the Study of Diabetes (EASD); Brussels, 9-13 September 1999.
  • Yki-Jarvinen H., Dressler A., Ziemen M. Less nocturnal hypoglycaemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group. Diabetes Care 2000;23:1130-6.[Abstract/Free Full Text]
  • Rosenstock J., Riddle M., Dailey G., Gerich J., Mecca T., Wilson C., Bugos C. Treatment to target study: feasibility of achieving control with the addition of basal bedtime insulin glargine (Lantus®) or NPH in insulin-naïve patients with type 2 diabetes on oral agents [poster]. American Diabetes Association, 61st Scientific Sessions, Philadelphia, USA, 22-26 June 2001.
  • Witthaus E., Stewart J., Bradley C. Treatment satisfaction and psychological well-being with insulin glargine compared with NPH in patients with type 1 diabetes. Diabetic Med 2001;8:619-25.
  • Witthaus E., Stewart J., Bradley C. Improved psychological outcomes after initiation of insulin treatment in patients with type II diabetes. Abstract. Diabetologia 2000;43(suppl 1):A205.

The British Journal of Diabetes & Vascular Disease, Vol. 2, No. 5, 403-406 (2002)
DOI: 10.1177/14746514020020051101


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Owens, D. R.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?