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Vascular disease and survival in patients with type 2 diabetes and nephropathy

Renal Unit, Glasgow Royal Infimary, Castle Street

Kenneth R Paterson

Diabetic Unit, Glasgow Royal Infirmary, Castle Street, Glasgow, G4 0SF, UK

Christopher J Deighan

Renal Unit, Glasgow Royal Infimary, Castle Street

Keith Simpson

Renal Unit, Glasgow Royal Infimary, Castle Street

J Michael Boulton-Jones

Renal Unit, Glasgow Royal Infimary, Castle Street

Diabetic nephropathy in patients with type 2 diabetes is associated with progressive renal failure and accelerated cardiovascular disease. We performed a retrospective review of 126 patients who presented to a combined diabetic-renal clinic between 1989 and 1999. We analysed the prevalence of vascular disease, cardiovascular risk factors and the use of cardioprotective drugs. Patient survival was analysed and poor prognostic indicators were identified. At referral, 68% had documented vascular disease, mean blood pressure (BP) was 162/84 mmHg, HbA1C 8.2% and cholesterol 6.2 mmol/L. Significant improvements were achieved in BP and cholesterol. Median patient survival from time of referral was 61 months. Seventy-three percent of deaths were a consequence of vascular disease. Factors predicting death at referral were low haemoglobin, low creatinine clearance, high albumin: creatinine ratio, lack of use of aspirin and female sex. These data highlight the extent of vascular disease and poor survival in patients with type 2 diabetes and nephropathy. The importance of early cardioprotection is emphasised.

Key Words: type 2 diabetes • nephropathy • macrovascular disease.

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The British Journal of Diabetes & Vascular Disease, Vol. 2, No. 2, 137-142 (2002)
DOI: 10.1177/14746514020020021201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Joss, N. Articles by Boulton-Jones, J M. Search for Related Content Social Bookmarking                         What's this?