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Effect of losartan on insulin sensitivity and serum lipids in hypertensive type 2 diabetic patients

Department of Medicine, Llandough Hospital

Kahlid Ahmed

Diabetes Research Unit, Llandough Hospital, Cardiff, Wales, UK

Stephen Luzio

Diabetes Research Unit, Llandough Hospital, Cardiff, Wales, UK

David R Owens

Diabetes Research Unit, Llandough Hospital, Cardiff, Wales, UK

John H Lazarus

Department of Medicine, Llandough Hospital, Lazarus @cf.ac.uk

Background Insulin resistance and hypertension are common co-existing conditions. Antihypertensive agents have differing effects on insulin sensitivity (SI). We studied 11 mildly hypertensive insulin-resistant type 2 diabetic patients to observe any changes in SI, glucose effectiveness (SG), serum total cholesterol, serum triglycerides and blood pressure (BP) with the introduction of the angiotensin II inhibitor, losartan.

Methods To assess SI and SG, we used the frequently sampled, intravenous glucose tolerance test with minimal model analysis prior to and after three months treatment with losartan potassium 50—100 mg daily. BP was assessed using a Space Labs 24-hour BP recording device before, during and after treatment with losartan.

Results There were no significant differences in SI and SG pre-and post-treatment, however, there was a non-significant reduction in mean BP, total cholesterol and triglyceride concentrations.

Conclusion There were no adverse effects of losartan on SI or SG. The lower but non-significant serum total cholesterol and triglyceride concentrations warrant further study.

Key Words: insulin sensitivity • minimal model • type 2 diabetes • hypertension.

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The British Journal of Diabetes & Vascular Disease, Vol. 2, No. 1, 67-68 (2002)
DOI: 10.1177/14746514020020010901


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mulcahy, M. P Articles by Lazarus, J. H Search for Related Content Social Bookmarking                         What's this?