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The role of central fat accumulation in type 2 diabetes
Mike EJ Lean
University Department of Human Nutrition, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK, mej.lean{at}clinmed.gla.ac.uk
This article examines the merits of body mass index (BMI), waist and hip measurements as indicators of total body fat and diabetes risk. Diabetes risk increases with obesity, with the accumulation of central fat being closely related with insulin resistance. This promotes other features of metabolic syndrome, including glucose intolerance, to increase vascular risk.
Key Words: type 2 diabetes abdominal obesity.
References
- Lean MEJ, Han TS, Deurenberg P. Predicting body composition by body density from simple anthropometric measurements. Am J Clin Nutr 1996;63:4-14.[Abstract/Free Full Text]
- Colditz GA, Willett WC, Rotnitzky A., Manson JE Weight gain as a risk factor for clinical diabetes in women. Annals Int Med 1995;122:481-6.[Abstract/Free Full Text]
- UK Prospective Diabetes Study. Complications in newly diagnosed diabetic patients and their associations with different clinical and biochemical risk factors. Diabetes Res 1990;13:1-11.[Medline]
[Order article via Infotrieve]
- Lean MEJ, Han TS, Seidell JC Impairment of health and quality of life in people with large waist circumference. Lancet 1998;351:853-6.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Han TS, Lean MEJ. Self-reported waist circumference compared with the "Waist Watcher" tape-measure to identify individuals at increased health risk through intra-abdominal fat accumulation. Br J Nutr 1998;80:81-8.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Han TS, Feskens EJM, Lean MEJ, Seidell JC Associations of body composition with non-insulin dependent diabetes mellitus. Diabetic Med 1998;15:129-35.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Lissner L., Bjorkelund C., Heitmann BL, Seidell JC, Bengtsson C. Hip-Hip-Hurrah! Larger hip circumference independently predicts health and longevity in a Swedish female cohort. Obesity Res 2001(in press).
- Han TS, McNeill G., Seidell JC, Lean MEJ. Predicting intra-abdominal fatness from anthropometric measures: the influence of stature. Int J Obes 1997;21:587-93.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Chan JM, Stampfer MJ, Rimm EB, Willett WC, Colditz GA Obesity, fat distribution and weight gain as risk factors for clinical diabetes in men. Diabetes Care 1994;9:961-9.
- Wei M., Gaskill SP, Haffner SM, Stern MP Waist circumference as the best predictor of noninsulin dependent diabetes mellitus (NIDDM) compared to body mass index, waist/hip ratio and other anthropometric measurements in Mexican Americans - a 7 year prospective study. Obesity Res 1997;5:16-23.[Web of Science][Medline]
[Order article via Infotrieve]
- Han TS, Lean MEJ. Metabolic syndrome. Medicine 1998;26:27-9.
- Lean MEJ. Abdominal adipose tissue distribution in diabetes, Cushings syndrome and phaeochromocytoma. Proc Nutr Soc 1986;46:19A.
- Arner P. Catecholamine-induced lipolysis in obesity. Int J Obes 1999;23 (suppl 1):10-13.[Web of Science]
- Randle PJ, Hales CN, Garland PB et al. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-9.[Web of Science][Medline]
[Order article via Infotrieve]
- Leibel RL, Eddens NK, Fried SK Physiological basis for the control of body fat distribution in humans. Annu Rev Nutr 1989;9:417-43.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Saltiel ST You are what you secrete. Nature 2001;7:887-8.[CrossRef][Web of Science]
- Barker DJP. Fetal and infant origins of adult disease. London: BMJ 1992.
- Han TS, McNeill G., Campbell DM The relationship between women's birth weight and their current intra-abdominal fat mass. Proc Nutr Soc 1995;54:182A.
- Kelly IE, Han TS, Walsh K., Lean MEJ. The effects of a thiazolidinedione compound on body composition of patients with type 2 diabetes. Diabetes Care 1999;22:288-93.[Abstract/Free Full Text]
- Lean MEJ, Priest M., Stump S., Martin M., Gibson C., Edwards G. Pioglitazone reduces intra-abdominal fat. Diabetologia 2001;44 (suppl): 847A.
- Lean MEJ. Is long-term weight loss possible? Br J Nutr 2000;83(suppl 1): S103-11.[Web of Science][Medline]
[Order article via Infotrieve]
The British Journal of Diabetes & Vascular Disease, Vol. 1, No. 2,
115-117 (2001)
DOI: 10.1177/14746514010010020901

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