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The Diabetes Prevention Program: headline results

Diabetes Group, School of Pharmacy, Aston University, Birmingham, B4 7ET, c.j.bailey{at}aston.ac.uk

The Diabetes Prevention Program (DPP) was a trial of over 3,000 people with impaired glucose tolerance (IGT) to assess the effect of different interventions on their progression to type 2 diabetes. During an average follow-up period of three years, intensive lifestyle intervention with regular exercise and weight loss reduced the risk of progression to type 2 diabetes by 58%. Treatment with the antihyperglycaemic agent metformin reduced progression to type 2 diabetes by 31%. The DPP has therefore confirmed that rigorous lifestyle management can reduce the risk of type 2 diabetes and also shown that metformin therapy can reduce diabetes risk.

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The British Journal of Diabetes & Vascular Disease, Vol. 1, No. 1, 62-64 (2001)
DOI: 10.1177/14746514010010011001


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