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The British Journal of Diabetes & Vascular Disease
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Review: Diabetes in pregnancy: insulin resistance, obesity and placental dysfunction

Anjum Doshani

Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK

Justin C Konje

Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK, jck4{at}le.ac.uk

Obesity in pregnancy is linked to increased morbidity and mortality for mother and baby. The incidence of gestational diabetes is increased approximately two to six-fold in women who are overweight-obese and the presence of diabetes is a further metabolic challenge which is associated with adverse outcomes. Herein the role of obesity is discussed in the generation of insulin resistance and inflammation and its contribution to placental dysfunction.

Key Words: placental dysfunction • insulin resistance • obesity.

The British Journal of Diabetes & Vascular Disease, Vol. 9, No. 5, 208-212 (2009)
DOI: 10.1177/1474651409350273
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The British Journal of Diabetes & Vascular Disease, September 1, 2009; 9(5): 197 - 199.
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