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The British Journal of Diabetes & Vascular Disease
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Is non-dipping of nocturnal blood pressure in type 2 diabetes associated with increased incidence of microalbuminuria?

Alison J Heggie

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK

Karen A Adamson

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK, k.a.adamson{at}ed.ac.uk

Riccardo E Marioni

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK

Paul L Padfield

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK

Mark Wj Strachan

Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, UK

icroalbuminuria has been associated with Mnon-dipping of nocturnal blood pressure (BP) in people with type 2 diabetes, but the mechanism of this association is unclear. We aimed to identify the development of microalbuminuria in patients with nocturnal non-dipping of BP and type 2 diabetes. Data were examined from 150 people with type 2 diabetes who had undergone ambulatory BP monitoring, non-dippers were defined as those with a systolic nocturnal BP dip less than 10% of the daytime BP.

The development of microalbuminuria, over five years of follow-up, in dippers and non-dippers was not significantly different. Non-dippers who were microalbuminuric at baseline were more likely to have a higher body mass index (p=0.01) and to be male (p<0.01).

This lack of a difference may be due to the initial exclusion of microalbuminuric patients, who may be genetically predetermined to develop microalbuminuria. Further prospective trials are required to investigate this relationship.

Key Words: ambulatory blood pressure • dipping • nephropathy • non-dipping • type 2 diabetes.

The British Journal of Diabetes & Vascular Disease, Vol. 8, No. 3, 136-139 (2008)
DOI: 10.1177/14746514080080030501
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