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The British Journal of Diabetes & Vascular Disease
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Review: Thinking around abdominal obesity and cardiovascular risk

Iain Broom

Robert Gordon University and NHS Grampian, St Andrew Street, Aberdeen, AB25 1HG, Scotland, ext.broom{at}rgu.ac.uk

Obesity, particularly intra-abdominal (visceral) obesity, is a leading cause of cardiovascular disease (CVD), insulin resistance, type 2 diabetes, dyslipidaemia, inflammation and thrombosis. A useful indicator for visceral fat is waist circumference, which is associated with all-cause mortality. Pro-inflammatory adipokines play a causal role in the development of pathologies associated with insulin resistance, type 2 diabetes and CVD. In addition to established anti-obesity therapies, namely orlistat and sibutramine, a new type of agent that inhibits the cannabinoid receptor (CB1) is advanced in development to reduce appetite and act predominantly against intra-abdominal adiposity.

Key Words: abdominal obesity • metabolic syndrome • visceral fat • waist circumference • cardiometabolic risk.

The British Journal of Diabetes & Vascular Disease, Vol. 6, No. 2, 58-61 (2006)
DOI: 10.1177/14746514060060020301
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