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Association of albuminuria with all-cause and cardiovascular disease mortality in diabetes: the Strong Heart Study

Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA, susan-xu{at}ouhsc.edu

Elisa T Lee

Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

Lyle G Best

Missouri Breaks Industries Research Inc, Timber Lake, SD, USA

Momotaz Begum

Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

William C Knowler

National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, AZ, USA

Richard R Fabsitz

National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

Barbara V Howard

Medstar Research Institute, Hyattsville, MD, USA

Objectives — To estimate the relative risks of albuminuria with all-cause and cardiovascular disease (CVD) mortality in a large cohort of American Indians with diabetes. Methods — A total of 1,953 diabetic participants in the Strong Heart Study were evaluated based on albuminuria categories at baseline examination. The Cox proportional hazards model was used to examine associations. Results — Of the 1,953 participants, 605 (31%) and 410 (21%) had microalbuminuria and macroalbuminuria, respectively, at baseline examination. Microalbuminuria (HR=1.42, 95% CI 1.15—1.77 for all-cause, and HR=1.48, CI 1.01—2.17 for CVD), and macroalbuminuria (HR=3.39, CI 2.71—4.25 for all-cause, and HR=3.74, CI 2.56—5.47 for CVD) were significant predictors for all-cause and CVD mortality after adjustment for other CVD risk factors. Conclusions — Results from the present study suggest that albuminuria is a strong independent predictor of all-cause and CVD Mortality in American Indians with diabetes.

Key Words: albuminuria • cardiovascular disease mortality • association • diabetes • American Indians.

The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 6, 334-340 (2005)
DOI: 10.1177/14746514050050060701


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