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The British Journal of Diabetes & Vascular Disease
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Review: Insulin secretion: function and therapy of pancreatic beta-cells in diabetes

Patrik Rorsman

Oxford Centre for Diabetes, Endocrinology; and Metabolism, Churchill Hospital, University of Oxford, Oxford, OX3 7LJ, UK, patrik.rorsman{at}drl.ox.ac.uk

nsulin is secreted from the beta-cells of the pancreatic islets in response to an elevation of blood glucose concentration. This review describes a current view of the metabolic control of insulin secretion and the molecular mechanisms involved, including the role played by the beta-cell to ensure correct release of insulin as a result of electrical signals. It then considers what goes wrong in type 2 diabetes, a disease resulting from insufficient insulin secretion. It focuses on the influence of genetics exploring the theory of a genetic predisposition to type 2 diabetes, as well as the roles played by age and obesity. Finally, the mode of action of the hypoglycaemic sulphonylureas is discussed and the potential implications for the beta-cell associated with a sulphonylurea-based therapy.

Key Words: type 2 diabetes • insulin secretion • insulin resistance • beta-cell.

The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 4, 187-191 (2005)
DOI: 10.1177/14746514050050040201
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 British Journal of Diabetes & Vascular DiseaseHome page
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Tight glycaemic control: the key to improving the management of type 2 diabetes
The British Journal of Diabetes & Vascular Disease, July 1, 2005; 5(4): 184 - 185.
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