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The British Journal of Diabetes & Vascular Disease
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Review: Development and therapeutic potential of incretin hormone analogues for type 2 diabetes

Brian D Green

School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, b.green{at}ulster.ac.uk

Nigel Irwin

Victor A Gault

Finbarr Pm O'Harte

Peter R Flatt

The rising prevalence of type 2 diabetes and increasing burden of diabetic complications requires new approaches to diabetes therapy. An encouraging new approach for development of future anti-diabetic drugs is based on analogues of incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Both peptides reduce postprandial glucose by stimulating glucose-dependent insulin release and exert a number of other beneficial actions including trophic effects on the beta-cell. Efforts are currently focused on developing stable analogues of GLP-1 and GIP which are resistant to dipeptidylpeptidase IV mediated degradation and renal filtration. Thus, by increasing the half-life and potency of these incretins, they should become a new class of agents for the treatment of type 2 diabetes.

Key Words: GLP-1 • GIP • incretin hormones • diabetes.

The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 3, 134-140 (2005)
DOI: 10.1177/14746514050050030401
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