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The British Journal of Diabetes & Vascular Disease
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Raising HDL-C and lowering triglycerides: benefits beyond LDL-C modification

James Shepherd

Department of Vascular Biochemistry, Division of Cardiovascular and Medical Sciences, Macewen Building, Glasgow Royal Infirmary, North Glasgow University Hospital Division, 8 Alexandra Parade, Glasgow, G31 2ER, UK, sbrownlie{at}clinmed.gla.ac.uk

Reduction of low-density lipoprotein cholesterol (LDL-C) is central to the management of cardiovascular risk associated with dyslipidaemia. Yet, at best, this strategy is only capable of a reduction of about 50% in ischaemic vascular disease. Therefore, there is still a need for interventive strategies to improve the situation. Triglyceride lowering and high-density lipoprotein cholesterol (HDL-C) elevation feature prominently in this context, a viewpoint increasingly adopted by international treatment guidelines. This article reviews current thinking on the subject and offers additional treatment strategies for the dyslipidaemic patient.

Key Words: low and high-density lipoproteins • apolipoprotein B • apolipoprotein AI • fibrates • statins • nicotinic acid.

The British Journal of Diabetes & Vascular Disease, Vol. 5, No. 1 suppl, S12-S16 (2005)
DOI: 10.1177/14746514050050010401
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