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The British Journal of Diabetes & Vascular Disease
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The `polypill' to reduce cardiovascular risk: proof of concept

Data from the Steno-2 multifactorial intervention study in type 2 diabetes supports the `polypill' strategy to reduce cardiovascular risk

Vinod Patel

Warwick Medical School, Division of Medical Education, University of Warwick, Coventry, CV4 7AL, UK, vinod.patel{at}geh.nhs.uk

Oluf Pedersen

Steno Diabetes Center, Copenhagen, Denmark

John Morrissey

Diabetes and Endocrinology Centre, George Eliot Hospital NHS Trust, Nuneaton, England, UK

Hans-Henrik Parving

Steno Diabetes Center, Copenhagen, Denmark

Peter Gæde

Steno Diabetes Center, Copenhagen, Denmark

James Douglas Lee

Diabetes and Endocrinology Centre, George Eliot Hospital NHS Trust, Nuneaton, England, UK

This article considers data from the Steno-2 multifactorial intervention study in type 2 diabetes to which are applied the United Kingdom Prospective Diabetes Study (UKPDS) risk engine. Mathematical analyses support the use of a `polypill' to reduce cardiovascular risk in type 2 diabetes. It is suggested that the Polypill should include a statin, antihypertensive agents and aspirin.

Key Words: cardiovascular • type 2 diabetes • lipids • hypertension.

The British Journal of Diabetes & Vascular Disease, Vol. 4, No. 5, 339-341 (2004)
DOI: 10.1177/14746514040040051001
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