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The British Journal of Diabetes & Vascular Disease
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Assessment of postprandial glucose: relationship between a standardised continental breakfast and the oral glucose tolerance test

Alain Golay

Service of Therapeutical Education for Chronic Diseases, University Geneva Hospital, Geneva, Switzerland, Alain.Golay{at}hcuge.ch

Christiane Guitard

Novartis Pharma AG, Basel, Switzerland

Monique Hoyer

Novartis Pharma AG, Basel, Switzerland

John O Logan

Novartis Pharma AG, Basel, Switzerland

Patrick C Brunel

Novartis Pharma AG, Basel, Switzerland

Background

To determine the relationship between postprandial glucose(PPG) and insulin values after an oral glucose tolerance test (OGTT) and a standardised continental breakfast.

Methods

An open, single-centre, randomised, crossover study in 32 fasted patients with type 2 diabetes and 10 healthy volunteers. Plasma glucose and insulin concentrations following a standardised breakfast challenge and a 75 g OGTT were measured over two hours.

Results

In both groups, the standardised breakfast induced similar plasma glucose and insulin profiles to the OGTT. Mean PPG excursions at each time-point were 1—2 mmol/L greater following the OGTT than the breakfast. Two-hour OGTT glucose levels correlated highly (r ≥ 0.80) with those following the breakfast at all time-points between 0.5—2 hours.

Conclusion

Plasma glucose levels measured 0.5—2 hours following a standardised breakfast are useful for assessing postprandial hyperglycaemia for diagnostic or post-treatment evaluations.

Key Words: OGTT • standardised breakfast challenge • post-prandial glucose evaluation.

The British Journal of Diabetes & Vascular Disease, Vol. 4, No. 5, 321-324 (2004)
DOI: 10.1177/14746514040040050601
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