Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
The British Journal of Diabetes & Vascular Disease
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Jayapaul, M. K
Right arrow Articles by Walker, M.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Reviews

Review: Mechanisms contributing to the development of type 2 diabetes

Muthu K Jayapaul

Mark Walker

School of Clinical Medical Sciences, 4th Floor William Leech Block, The Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK, mark.walker{at}ncl.ac.uk

We are in the midst of an explosion in the prevalence of type 2 diabetes with a key concern that this will translate into a major future burden of diabetes-related complications. To develop rational and effective means of preventing type 2 diabetes and its complications, we need to understand the mechanisms that predispose to the development of diabetes in at-risk individuals. In this brief review, we provide an overview of the principal metabolic changes that have been identified in at-risk individuals and how they contribute to the progression from normal glucose tolerance (NGT) through to type 2 diabetes. Specifically, both impaired insulin action and defective insulin secretion are key predictors of type 2 diabetes, and both are evident in at-risk individuals well before the development of frank diabetes. These changes are associated with an increased prevalence of adverse cardiovascular risk factors. It is clear, therefore, that the identification of at-risk individuals provides the opportunity to introduce measures to try to prevent the development of type 2 diabetes and the associated cardiovascular disease.

Key Words: type 2 diabetes • impaired glucose tolerance • impaired fasting glycaemia • insulin resistance • beta-cell dysfunction.

The British Journal of Diabetes & Vascular Disease, Vol. 4, No. 4, 227-231 (2004)
DOI: 10.1177/14746514040040040201
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?