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What are the clinical manifestations of cardiovascular disease in diabetes? Ten year analysis from a clinic based population

Department of Diabetes & Endocrinology, UCL Hospitals, Mortimer Street, London, W1T 3AA, UK, rmhajst{at}ucl.ac.uk, Centre for Cardiovascular Genetics, Department of Medicine, University College London, 5 University Street, London, W1CE 6JF, UK

Steve E Humphries

Centre for Cardiovascular Genetics, Department of Medicine, University College London, 5 University Street, London, W1CE 6JF, UK

Jacqueline A Cooper

Centre for Cardiovascular Genetics, Department of Medicine, University College London, 5 University Street, London, W1CE 6JF, UK

Steven J Hurel

Department of Diabetes & Endocrinology, UCL Hospitals, Mortimer Street, London, W1T 3AA, UK

Aims

Cardiovascular disease may manifest as CHD, PVD and CbVD. Our aim was to explore these interactions and associated risk factors.

Methods

Patients were identified who attended clinic in 1990—1991 and remained under follow-up in 2000—2001. The latter were categorised by the presence/absence of manifest CHD, PVD and CbVD. Baseline clinic measurements (1990—1991) were studied in relation to CVD manifestations.

Results

Seven hundred and ninety-eight (CVD:358) patients were identified with follow-up. Of those with CVD: 51% had CHD, 14% PVD, and 9% CbVD exclusively. A further 17% had CHD+PVD, 4% CHD+CbVD, 2% PVD+CbVD, while 3% of patients had all three manifestations together. Increasing age, LDL-cholesterol and glucose were associated with increased risk of CHD, PVD and CbVD.

Conclusions

The majority of diabetic patients with CVD have $CHD (75%), and only 3% have a combination of CHD, PVD and CbVD.

Key Words: cardiovascular disease • coronary heart disease • peripheral vascular disease • diabetes • risk factors.

The British Journal of Diabetes & Vascular Disease, Vol. 4, No. 3, 190-194 (2004)
DOI: 10.1177/14746514040040030801


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