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The British Journal of Diabetes & Vascular Disease
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Review: Pharmacology of insulin

Bushra Ahmad

Department of Diabetes, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK, bushra.ahmad{at}orh.nhs.uk

Diabetes is associated with microvascular and macrovascular complications leading to significant morbidity and mortality. Glycaemic control is important to prevent and delay the progression of these complications. An ideal insulin regimen in patients with diabetes would mirror the 24-hour insulin profile of a non-diabetic person and thereby prevent hyperglycaemia without inducing hypoglycaemia. This has, until recently, proved difficult to reproduce by regular subcutaneous insulin injections due to the inherent pharmacokinetic properties of the available insulins. Normoglycaemia was rarely achieved without hypoglycaemia compromising the quality of patients' lives. The advent of the new long- and short-acting insulin analogues are expected to both improve glycaemic control leading to a reduction in diabetes-related complications and reduce the incidence of hypoglycaemia thereby offering patients a better lifestyle.

Key Words: insulin • pharmacology • analogues • lispro • aspart • glargine • detemir.

The British Journal of Diabetes & Vascular Disease, Vol. 4, No. 1, 10-14 (2004)
DOI: 10.1177/14746514040040010201
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 British Journal of Diabetes & Vascular DiseaseHome page
C. L Acerini and A. Deeb
Review: New approaches to insulin therapy in children and adolescents with type 1 diabetes
The British Journal of Diabetes & Vascular Disease, January 1, 2004; 4(1): 16 - 20.
[Abstract] [PDF]