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The British Journal of Diabetes & Vascular Disease
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Optimising treatment of hypertension to prevent cardiovascular complications in type 2 diabetes

Caroline Daly

Department of Cardiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK, c.daly{at}rbh.nthames.nhs.uk

Henry Purcell

Diabetes is associated with an increased risk of cardiovascular disease which is amplified in the presence of hypertension. Tight control of blood pressure (BP) reduces cardiovascular events in patients with type 2 diabetes. It has been suggested that drugs which interrupt the renin-angiotensin system (RAS) may be superior to other classes of antihypertensive agents. This review assesses the evidence for this suggestion, focusing on recently reported trials including ALLHAT, ANBP2, LIFE, and SCOPE. The evidence suggests that antihypertensive agents which interrupt the RAS offer benefits for diabetic patients with multiple cardiovascular risk factors.

Key Words: type 2 diabetes • renin-angiotensin system inhibition • cardiovascular events.

The British Journal of Diabetes & Vascular Disease, Vol. 3, No. 4, 274-276 (2003)
DOI: 10.1177/14746514030030040701
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