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The British Journal of Diabetes & Vascular Disease
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Dyslipidaemia in type 2 diabetes: epidemiology and biochemistry

Jonathan Valabhji

Department of Endocrinology and Metabolic Medicine, Imperial College School of Medicine, 1st Floor Mint Wing, St Marys Hospital, Praed Street, London, W2 1NY, UK, j.valabhji{at}ic.ac.uk

Robert S Elkeles

Lipid abnormalities in type 2 diabetes are characterised by high triglyceride concentrations, low high density lipoprotein-cholesterol concentrations, and normal total and low density lipoprotein-cholesterol (LDL-c) concentrations. LDL particles, however, are small and dense. Epidemiological evidence for these lipid abnormalities, and for the associations between lipid abnormalities and the increased risk of cardiovascular disease in type 2 diabetes, are presented. Most, of the lipid abnormalities in type 2 diabetes can be explained by reduced action of insulin at the tissue level. The biochemical and metabolic mechanisms underlying the lipid abnormalities are discussed.

Key Words: dyslipidaemia • type 2 diabetes • insulin action • cardiovascular disease.

The British Journal of Diabetes & Vascular Disease, Vol. 3, No. 3, 184-189 (2003)
DOI: 10.1177/14746514030030030501
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