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Failure to define the pathogenesis and treatment of human diabetic neuropathy

Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK, Rayaz.A.Malik{at}man.ac.uk

The clinical manifestations, underlying pathology and aetiology of human diabetic neuropathy are varied and complex. Much data has been generated from preclinical models to provide a conceptual framework for the cause and treatment of human diabetic neuropathy. Despite this there remains much debate and controversy on the pathophysiology of the condition. Furthermore, many of the interventions reaching phase III clinical trials have failed to prove effective. To date we have no evidence-based and effective treatment(s) for human diabetic neuropathy.

Key Words: diabetes • neuropathy • metabolic • vascular • clinical trials.

The British Journal of Diabetes & Vascular Disease, Vol. 3, No. 2, 107-111 (2003)
DOI: 10.1177/14746514030030020501


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